Perfringolysin O: The Underrated Clostridium perfringens Toxin?
| Autor: | Rodney K. Tweten, Filip Van Immerseel, Bart Pardon, Evy Goossens, Piet Deprez, Kristin R. Wade, Richard Ducatelle, Bonnie Valgaeren, Stefanie Verherstraeten, Leen Timbermont, Freddy Haesebrouck |
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| Rok vydání: | 2015 |
| Předmět: |
Clostridium perfringens
Health Toxicology and Mutagenesis Bacterial Toxins Clostridium perfringens toxin gas gangrene lcsh:Medicine THIOL-ACTIVATED CYTOLYSIN Review Biology Toxicology Cholesterol-dependent cytolysin medicine.disease_cause cholesterol-dependent cytolysin calves Microbiology Hemolysin Proteins 03 medical and health sciences medicine Animals Humans necrohemorrhagic enteritis 030304 developmental biology 0303 health sciences Pore-forming toxin INTRAVENOUS-INJECTION MODEL 030306 microbiology Toxin enterotoxaemia lcsh:R Cell Membrane Biology and Life Sciences TRANSMEMBRANE BETA-HAIRPINS THETA-TOXIN medicine.disease ENDOTHELIAL-CELLS PHOSPHOLIPASE-C 3. Good health myonecrosis MEDIATED GAS-GANGRENE CHOLESTEROL-DEPENDENT CYTOLYSIN PORE-FORMING TOXINS ALPHA-TOXIN Cytolysin Gas gangrene Perfringolysin O |
| Zdroj: | Toxins TOXINS Toxins, Vol 7, Iss 5, Pp 1702-1721 (2015) |
| ISSN: | 2072-6651 |
| DOI: | 10.3390/toxins7051702 |
| Popis: | The anaerobic bacterium Clostridium perfringens expresses multiple toxins that promote disease development in both humans and animals. One such toxin is perfringolysin O (PFO, classically referred to as theta toxin), a pore-forming cholesterol-dependent cytolysin (CDC). PFO is secreted as a water-soluble monomer that recognizes and binds membranes via cholesterol. Membrane-bound monomers undergo structural changes that culminate in the formation of an oligomerized prepore complex on the membrane surface. The prepore then undergoes conversion into the bilayer-spanning pore measuring approximately 250-300 angstrom in diameter. PFO is expressed in nearly all identified C. perfringens strains and harbors interesting traits that suggest a potential undefined role for PFO in disease development. Research has demonstrated a role for PFO in gas gangrene progression and bovine necrohemorrhagic enteritis, but there is limited data available to determine if PFO also functions in additional disease presentations caused by C. perfringens. This review summarizes the known structural and functional characteristics of PFO, while highlighting recent insights into the potential contributions of PFO to disease pathogenesis. |
| Databáze: | OpenAIRE |
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