Semisynthetic routes to PF1022H--A precursor for new derivatives of the anthelmintic cyclooctadepsipeptide PF1022A
| Autor: | Sivatharushan Sivanathan, Florian Körber, Jürgen Scherkenbeck |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Anthelmintics
010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Stereoisomerism Oxidation reduction 010402 general chemistry 01 natural sciences Biochemistry Peptides Cyclic 0104 chemical sciences Baeyer–Villiger oxidation Depsipeptides Drug Discovery medicine Molecular Medicine Emodepside Anthelmintic Molecular Biology Oxidation-Reduction medicine.drug |
| Zdroj: | Bioorganicmedicinal chemistry. 24(4) |
| ISSN: | 1464-3391 |
| Popis: | The cyclooctadepsipeptide PF1022A and its semisynthetic, commercial analogue emodepside show excellent anthelmintic properties. Bis-hydroxy PF1022 (PF1022H), a minor fermentative side-product represents an interesting precursor for new PF1022 related anthelmintics. We report herein two complementary routes which allow a highly efficient conversion of PF1022A to a regioisomeric mixture consisting mainly of the bis-para isomer PF1022H and the meta-para analogue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect