Langerhans Cells in Connective Tissue Diseases
| Autor: | M. Fang, J. P. Goobar, I. Gigli, N. J. Zvaifler, Michael H. Weisman |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Langerhans cell Biopsy ATPase Immunology Population Connective tissue Lupus Erythematosus Discoid Rheumatology Humans Lupus Erythematosus Systemic Immunology and Allergy Medicine Connective Tissue Diseases education Aged Skin Adenosine Triphosphatases education.field_of_study Scleroderma Systemic integumentary system biology business.industry Progressive systemic sclerosis General Medicine Middle Aged medicine.disease Staining medicine.anatomical_structure Langerhans Cells biology.protein Female Normal skin business Densitometry |
| Zdroj: | Scandinavian Journal of Rheumatology. 16:273-279 |
| ISSN: | 1502-7732 0300-9742 |
| Popis: | We have conducted a quantitative analysis of Langerhans cells (LC) in skin biopsies of 20 patients with various connective tissue diseases. Clinically normal skin of SLE patients as well as lesional skin of DLE showed consistently normal LC densities as assessed using ATPase staining, anti-DR and anti-OKT6. Examination of LC in clinically involved skin of patients with scleroderma revealed an absolute or relative decrease in ATPase and OKT6 expression, while staining with anti-DR gave inconclusive results. Clinically normal skin of the same individuals showed basically normal LC density. These findings suggest that the perturbation of the LC population is probably an expression of a secondary local phenomenon, and does not reflect a more widespread derangement of the accessory cells in the skin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|