Neuropeptide tyrosine is expressed in ensheathing cells around the olfactory nerves in the rat olfactory bulb
| Autor: | Åke Dagerlind, N. Halasz, Ruud Ubink, Tomas Hökfelt, Xiaoqun Zhang |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Olfactory system medicine.medical_specialty Olfactory Nerve Guinea Pigs Central nervous system Fluorescent Antibody Technique Neuropeptide Biology Immunoenzyme Techniques Rats Sprague-Dawley Mice Olfactory mucosa Olfactory Mucosa Olfactory nerve Internal medicine medicine Animals Neuropeptide Y RNA Messenger In Situ Hybridization General Neuroscience Neuropeptide Y receptor Olfactory Bulb Rats Olfactory bulb Cell biology medicine.anatomical_structure Endocrinology Olfactory ensheathing glia Colchicine Neuroglia |
| Zdroj: | Neuroscience. 60:709-726 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/0306-4522(94)90499-5 |
| Popis: | The olfactory bulbs of young and adult normal rats and of colchicine-treated rats and of some other species were analysed for the presence of neuropeptide Y and neuropeptide Y messenger RNA, using immunohistochemistry at the light- and electron-microscopic levels and with in situ hybridization. In the rat and mouse, but not in monkey and guinea-pig, neuropeptide Y-like immunoreactivity and neuropeptide Y messenger RNA were observed in ensheathing cells in the olfactory nerve layer of the olfactory bulb and within nerve bundles in the olfactory mucosa. Double staining experiments revealed that neuropeptide Y-like immunoreactivity was often present in a restricted compartment, mainly the Golgi apparatus, of S-100 protein-positive ensheathing cells. After colchicine treatment a different distribution of neuropeptide Y-like immunoreactivity and neuropeptide Y messenger RNA was observed. Thus, in the outer olfactory nerve layer both neuropeptide Y-like immunoreactivity and neuropeptide Y messenger RNA disappeared, whereas in the inner part messenger RNA levels remained high and neuropeptide Y-like immunoreactivity was observed in many granule-like structures distributed diffusely in the cytoplasm. The present findings suggest that neuropeptide Y may be involved in the control of regeneration, growth and/or guiding of the axons of the olfactory sensory neurons, the only mammalian neurons known to have a continuous renewal and growth during adult life. |
| Databáze: | OpenAIRE |
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