Executive function in phenylketonuria (PKU): Insights from the Behavior Rating Inventory of Executive Function (BRIEF) and a large sample of individuals with PKU
| Autor: | Shawn E. Christ, Christopher Saville, Deborah A. Bilder, Mitzie Grant, Susan E. Waisbren, Desirée A. White, Barbara K. Burton, Marie Claire Paulin, Hayley E. Clocksin |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Aging Adolescent Short-term memory PsycINFO Neuropsychological Tests 050105 experimental psychology Executive Function Young Adult Phenylketonurias medicine Humans 0501 psychology and cognitive sciences Phenylketonuria (PKU) Young adult Child Problem Solving Working memory Working Memory Scale 05 social sciences Cognition Middle Aged medicine.disease Behavior Rating Inventory of Executive Function Memory Short-Term Neuropsychology and Physiological Psychology Child Preschool Female Psychology Clinical psychology |
| Zdroj: | Neuropsychology. 34:456-466 |
| ISSN: | 1931-1559 0894-4105 |
| DOI: | 10.1037/neu0000625 |
| Popis: | Objective Previous research has documented executive function (EF) impairments in individuals with early treated phenylketonuria (ETPKU). It remains unclear, however, whether some aspects of EF may be more affected than others. A number of factors, including small sample sizes and variability in EF tasks, have likely contributed to past mixed findings. The present objective was to elucidate further the EF profile associated with ETPKU, particularly as it relates to report-based assessment of EF. Method Data from 286 individuals (5-48 years of age) with ETPKU on the child and adult versions of the Behavior Rating Inventory of Executive Function (BRIEF), a well-established report-based assessment tool, were analyzed. Results The Working Memory scale showed the largest effect size in both young and older ETPKU samples, with 19% of children and 29% of adults scoring in the "abnormally elevated" range. In addition, EF impairment appeared more general (i.e., affecting more domains) in the adult sample as compared to the child sample. Exploratory analyses also suggested that the presence/absence of overall impairment on the BRIEF among our ETPKU participants could be predicted based on a small subset of items. A 10-item subset showed total classification accuracy values of 90% and above for both groups. Conclusions Working memory represents an aspect of EF that appears to be particularly affected in individuals with ETPKU. Findings also provide preliminary support of the viability for the development and/or adoption of an abbreviated screening measure for EF difficulties in children and adults with ETPKU. (PsycInfo Database Record (c) 2020 APA, all rights reserved). |
| Databáze: | OpenAIRE |
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