Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins*

Autor: Stefano Sinisi, Enrico Tronci, Brigitte Leeners, Vadim Alimguzhin, Toni Mancini, Federico Mari
Přispěvatelé: University of Zurich, Eiter, Thomas, Maratea, Marco, Vallati, Mauro, Sinisi, Stefano
Rok vydání: 2020
Předmět:
FOS: Computer and information sciences
medicine.medical_specialty
Computer Science - Artificial Intelligence
Computer science
Computation
610 Medicine & health
02 engineering and technology
1710 Information Systems
Quantitative Biology - Quantitative Methods
Theoretical Computer Science
Pharmacological treatment
03 medical and health sciences
0202 electrical engineering
electronic engineering
information engineering
medicine
Medical physics
Artificial Intelligence
Virtual Physiological Human
In Silico Clinical Trials
Simulation
Personalised Medicine
In Silico Treatment Optimisation
68T20 (Primary)
2614 Theoretical Computer Science
Quantitative Methods (q-bio.QM)
030304 developmental biology
Protocol (science)
0303 health sciences
Algebra and Number Theory
I.6.3
In silico clinical trials
I.2.8
10175 Clinic for Reproductive Endocrinology
Precision medicine
3. Good health
Artificial Intelligence (cs.AI)
Computational Theory and Mathematics
FOS: Biological sciences
020201 artificial intelligence & image processing
2602 Algebra and Number Theory
1703 Computational Theory and Mathematics
Information Systems
Zdroj: Fundamenta Informaticae. 174:283-310
ISSN: 1875-8681
0169-2968
DOI: 10.3233/fi-2020-1943
Popis: In Silico Clinical Trials (ISTC), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation--based experimental campaigns (ISTC) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine). e show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
31 pages, 9 figures
Databáze: OpenAIRE
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