Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project
| Autor: | Herbert D. Spapen, Massimo Girardis, Polychronis Tasioudis, Santi Maurizio Raineri, Jose Luis Garcia-Garmendia, Philippe Montravers, Valentino Tisa, Alessio Mesini, Massimo Antonelli, Novella Carannante, Stefano Ianniruberto, Jean-François Timsit, Mario Venditti, Filippo Ansaldi, Joost Wauters, Mario Tumbarello, Cecilia Trucchi, Matteo Bassetti, Manu L N G Malbrain, Katrien Lagrou, Silvia Corcione, Enora Atchade, Bart Jan Kullberg, Alessia Carnelutti, Cristiano Alicino, Pierluigi Brugnaro, José Artur Paiva, Riina Rautemaa-Richardson, Ana J Marques, Maria-Panagiota Almyroudi, George Dimopoulos, Clément Le Bihan, Andrea Cortegiani, Maria Merelli, Anna Maria Azzini, Simon Dubler, Daniele Roberto Giacobbe, Charlotte H S B van den Berg, Maddalena Peghin, Benoit Veber, Jeroen Schouten, Roberto Luzzati, Antonio Vena, Guillaume Voiriot, Oliver A. Cornely, Vaclava Adamkova, Ignacio Martin-Loeches |
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| Přispěvatelé: | Bassetti M., Giacobbe D.R., Vena A., Trucchi C., Ansaldi F., Antonelli M., Adamkova V., Alicino C., Almyroudi M.-P., Atchade E., Azzini A.M., Carannante N., Carnelutti A., Corcione S., Cortegiani A., Dimopoulos G., Dubler S., Garcia-Garmendia J.L., Girardis M., Cornely O.A., Ianniruberto S., Kullberg B.J., Lagrou K., Le Bihan C., Luzzati R., Malbrain M.L.N.G., Merelli M., Marques A.J., Martin-Loeches I., Mesini A., Paiva J.-A., Peghin M., Raineri S.M., Rautemaa-Richardson R., Schouten J., Brugnaro P., Spapen H., Tasioudis P., Timsit J.-F., Tisa V., Tumbarello M., Van Den Berg C.H.S.B., Veber B., Venditti M., Voiriot G., Wauters J., Montravers P., Bassetti, M., Giacobbe, D. R., Vena, A., Trucchi, C., Ansaldi, F., Antonelli, M., Adamkova, V., Alicino, C., Almyroudi, M. -P., Atchade, E., Azzini, A. M., Carannante, N., Carnelutti, A., Corcione, S., Cortegiani, A., Dimopoulos, G., Dubler, S., Garcia-Garmendia, J. L., Girardis, M., Cornely, O. A., Ianniruberto, S., Kullberg, B. J., Lagrou, K., Le Bihan, C., Luzzati, R., Malbrain, M. L. N. G., Merelli, M., Marques, A. J., Martin-Loeches, I., Mesini, A., Paiva, J. -A., Peghin, M., Raineri, S. M., Rautemaa-Richardson, R., Schouten, J., Brugnaro, P., Spapen, H., Tasioudis, P., Timsit, J. -F., Tisa, V., Tumbarello, M., Van Den Berg, C. H. S. B., Veber, B., Venditti, M., Voiriot, G., Wauters, J., Montravers, P., Faculty of Psychology and Educational Sciences, Supporting clinical sciences, Intensive Care, Internal Medicine Specializations |
| Rok vydání: | 2019 |
| Předmět: |
Male
Outcome Assessment lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] MULTICENTER Critical Care and Intensive Care Medicine law.invention 610 Medical sciences Medicine 0302 clinical medicine Retrospective Studie Risk Factors law Outcome Assessment Health Care EPIDEMIOLOGY Medicine Cumulative incidence PREDICTORS Candida Medicine(all) Cross Infection Incidence Incidence (epidemiology) lcsh:Medical emergencies. Critical care. Intensive care. First aid Candidiasis Middle Aged Intensive care unit Europe Intensive Care Units Abdominal candidiasis Candidemia ICU Aged Candidiasis Invasive Female Humans Retrospective Studies Candidiasi SOFA score Life Sciences & Biomedicine Human medicine.medical_specialty Invasive Intensive Care Unit Abdominal candidiasis Candida Candidemia Candidiasis ICU Incidence 03 medical and health sciences Critical Care Medicine General & Internal Medicine Intensive care Settore MED/41 - ANESTESIOLOGIA MANAGEMENT Science & Technology business.industry Septic shock INTRAABDOMINAL CANDIDIASIS Research 030208 emergency & critical care medicine Retrospective cohort study lcsh:RC86-88.9 Odds ratio medicine.disease Health Care lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Emergency medicine Abdominal candidiasi business |
| Zdroj: | Bassetti, M, Giacobbe, D R, Vena, A, Trucchi, C, Ansaldi, F, Antonelli, M, Adamkova, V, Alicino, C, Almyroudi, M, Atchade, E, Azzini, A M, Carannante, N, Carnelutti, A, Corcione, S, Cortegiani, A, Dimopoulos, G, Dubler, S, García-garmendia, J L, Girardis, M, Cornely, O A, Ianniruberto, S, Kullberg, B J, Lagrou, K, Le Bihan, C, Luzzati, R, Malbrain, M L N G, Merelli, M, Marques, A J, Martin-loeches, I, Mesini, A, Paiva, J, Peghin, M, Raineri, S M, Rautemaa-richardson, R, Schouten, J, Brugnaro, P, Spapen, H, Tasioudis, P, Timsit, J, Tisa, V, Tumbarello, M, Van Den Berg, C H S B, Veber, B, Venditti, M, Voiriot, G, Wauters, J & Montravers, P 2019, ' Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project ', Critical Care, vol. 23, no. 1 . https://doi.org/10.1186/s13054-019-2497-3 Critical Care Critical care (London, England), 23(1):219. BMC Critical Care, 23, 1, pp. 219 Critical Care, Vol 23, Iss 1, Pp 1-7 (2019) Critical Care, 23, 219 |
| ISSN: | 1364-8535 1466-609X |
| DOI: | 10.1186/s13054-019-2497-3 |
| Popis: | Contains fulltext : 206779.pdf (Publisher’s version ) (Open Access) BACKGROUND: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. METHODS: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). RESULTS: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. CONCLUSIONS: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions. |
| Databáze: | OpenAIRE |
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