Effect of Irradiation on Incidence of Post-Transplant Lymphoproliferative Disorder after Hematopoietic Cell Transplantation in Miniature Swine

Autor: Raimon Duran-Struuck, David H. Sachs, Aarti R. Patil, Christene A. Huang, Abraham J. Matar, Ahmad Al-Musa, I.M. Hanekamp
Rok vydání: 2015
Předmět:
Transplantation Conditioning
Swine
T-Lymphocytes
Calcineurin Inhibitors
Graft vs Host Disease
Miniature swine
Thymus Gland
Lymphocyte Depletion
Post-transplant lymphoproliferative disorder
Immunity
hemic and lymphatic diseases
medicine
Animals
Humans
Swine Diseases
Transplantation
Lymphatic Irradiation
Hematopoietic cell transplantation
L-Lactate Dehydrogenase
biology
business.industry
Incidence (epidemiology)
Hematopoietic Stem Cell Transplantation
Post-transplant lymphoproliferative disease
Hematology
Total body irradiation
medicine.disease
Herpesvirus 1
Suid
Lymphoproliferative Disorders
3. Good health
Calcineurin
Disease Models
Animal
Tumor Virus Infections
surgical procedures
operative
Histocompatibility
Immunology
Cyclosporine
biology.protein
Swine
Miniature
Antibody
business
Immunosuppressive Agents
Whole-Body Irradiation
Zdroj: Biology of Blood and Marrow Transplantation. 21(10):1732-1738
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2015.07.017
Popis: Post-transplant lymphoproliferative disease (PTLD) is a major complication of clinical organ and cell transplantation. Conditioning and immunosuppressive regimens that significantly impair T cell immunity, including depleting antibodies and calcineurin inhibitors, increase the risk of PTLD after transplantation. Swine PTLD has been shown to closely resemble human PTLD in morphology, histology, and viral-driven reactivation of B cells. Previously, we reported high incidences of PTLD after hematopoietic cell transplantation (HCT) in miniature swine recipients conditioned with thymic irradiation (TI) in addition to T cell depletion and cyclosporine A monotherapy after transplantation. Replacement of TI with 100 cGy of total body irradiation resulted in similar numbers of B cells early post-transplantation, greater numbers of T cells at day 0, and markedly decreased incidence of PTLD, suggesting that a threshold number of T cells may be necessary to prevent subsequent B cell proliferation and development of overt PTLD. Results from this large cohort of animals provide insight into the important effect of irradiation and T cell immunity on the incidence of PTLD after HCT and reinforce the pig model as a valuable tool for the study of PTLD and HCT.
Databáze: OpenAIRE
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