Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans
| Autor: | Pengyu Cao, Lin Zou, Rongyu Li, Yang Zheng, Wanqing Sun, Lin Wang, Zhenwei Gong, Wangshu Shao, Erick Forno, Radhika Muzumdar, He Cai |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male medicine.medical_specialty Myocardial Infarction Biophysics Coronary Artery Disease Biochemistry Angina Pectoris Coronary artery disease Angina Risk Factors Internal medicine medicine TBARS Humans cardiovascular diseases Myocardial infarction Risk factor Molecular Biology Humanin Inflammation Unstable angina business.industry Intracellular Signaling Peptides and Proteins Heart Middle Aged Prognosis medicine.disease Mitochondria Oxidative Stress Cardiology Female business Biomarkers Mace |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - General Subjects. 1866:130010 |
| ISSN: | 0304-4165 |
| DOI: | 10.1016/j.bbagen.2021.130010 |
| Popis: | Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography. Serum humanin and thiobarbituric acid reactive substances (TBARS) were measured at the time of initial admission. The hospitalization data and MACE of all patients were collected.Circulating humanin levels were lower in the angina group compared to controls [124.22 ± 63.02 vs. 157.77 ± 99.93 pg/ml, p 0.05] and even lower in MI patients [67.17 ± 24.35 pg/ml, p 0.05 vs controls] and oxidative stress marker were higher in MI patients compared to the control and angina groups [12.94 ± 4.55 vs. 8.26 ± 1.66 vs. 9.06 ± 2.47 umol/ml, p 0.05]. Lower circulating humanin levels was an independent risk factor of MI patients. Circulating humanin levels could be used to predict MACE in angina group.Lower circulating humanin levels was an independent risk factor for CAD, and a potential prognostic marker for mild CAD.Humanin may become a new index for the diagnosis and treatment of CAD. |
| Databáze: | OpenAIRE |
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