Heat shock protein 60 and cardiovascular diseases: An intricate love-hate story
| Autor: | C. Enrique Guerrero-Beltrán, Iván Alfredo Mijares-Rojas, Indumathi Krishnan-Sivadoss, Guillermo Torre-Amione, Anne A Knowlton, Ramiro A. Villarreal-Leal |
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| Rok vydání: | 2020 |
| Předmět: |
Cardiovascular homeostasis
chemical and pharmacologic phenomena Inflammation Apoptosis Cardiovascular System 03 medical and health sciences 0302 clinical medicine Immune system Immunity Heat shock protein Drug Discovery medicine Humans 030304 developmental biology Pharmacology 0303 health sciences biology business.industry Chaperonin 60 Acquired immune system Cardiovascular Diseases 030220 oncology & carcinogenesis Chaperone (protein) Immune System biology.protein Molecular Medicine HSP60 medicine.symptom business Neuroscience |
| Zdroj: | Medicinal research reviews. 41(1) |
| ISSN: | 1098-1128 |
| Popis: | Cardiovascular diseases (CVDs) are the result of complex pathophysiological processes in the tissues comprising the heart and blood vessels. Inflammation is the main culprit for the development of cardiovascular dysfunction, and it may be traced to cellular stress events including apoptosis, oxidative and shear stress, and cellular and humoral immune responses, all of which impair the system's structure and function. An intracellular chaperone, heat shock protein 60 (HSP60) is an intriguing example of a protein that may both be an ally and a foe for cardiovascular homeostasis; on one hand providing protection against cellular injury, and on the other triggering damaging responses through innate and adaptive immunity. In this review we will discuss the functions of HSP60 and its effects on cells and the immune system regulation, only to later address its implications in the development and progression of CVD. Lastly, we summarize the outcome of various studies targeting HSP60 as a potential therapeutic strategy for cardiovascular and other diseases. |
| Databáze: | OpenAIRE |
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