Liver Enzymes and Trace Elements in the Acute Phase of Sickle Cell Anaemia
| Autor: | M. O. Nezianya, O. M. Adewumi, M O Kehinde, S I Jaja, A. I. Adeniyi, EO Ayinla |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Cell Anemia Sickle Cell Young Adult Immune system Internal medicine Liver enzyme medicine Humans Platelet Aspartate Aminotransferases Sickle cell anaemia crisis irreversibly sickle cells liver enzymes platelets trace elements chemistry.chemical_classification biology business.industry Alanine Transaminase General Medicine Plasma levels Alkaline Phosphatase Trace Elements medicine.anatomical_structure Endocrinology Enzyme Liver Alanine transaminase chemistry Case-Control Studies Immunology biology.protein Alkaline phosphatase Female business |
| Zdroj: | West African Journal of Medicine; Vol 29, No 4 (2010) |
| ISSN: | 0189-160X |
| DOI: | 10.4314/wajm.v29i4.68244 |
| Popis: | Trace elements are required for the performance of numerous functions of immune cells. It is not clear whether levels of trace elements are elevated and whether there is a relationship between the levels of liver enzymes and trace elements in patients with sickle cell anaemia in crisis.To compare the plasma levels of liver enzymes and trace elements in non sickle cell anaemia (NSCA), sickle cell anaemia subjects in the steady state (SCASS) and sickle cell anaemia patients in crisis (SCAC).Haematological parameters, liver enzymes and trace elements were determined in 20 NSCA subjects, 20 SCASS subjects and 18 SCAC subjects. Variables studied included aspartate aminotransferase (AST) , alanine aminotransaminase (ALT), alkaline phosphatase (ALP), and the trace elements copper, zinc, and manganese.Levels of liver enzymes were higher in the SCAC subjects than in the NSCA or SCASS subjects (p0.001). Plasma Cu++, Zn++ and Mn++ were also higher in the SCAC subjects than in the NSCA or SCASS subjects (p0.001). Correlationships were high and strong between AST and ALT (r=+0.7; p=0.03), AST and ALP (r=+0.9; p=0.001), Zn++ and Fe++ (r=+0.9; p=0.001) in SCAC.During crisis in sickle cell anaemia, liver enzymes, as well as the trace elements of Cu++, Zn++ and Mn++ are increased; levels of aspartate aminotransaminase are strongly correlated with those of ALT and ALP. Levels of liver enzymes do not appear to be related to those of the trace elements in painful sickle cell crisis. |
| Databáze: | OpenAIRE |
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