Dermatofibrosarcoma protuberans: A retrospective study of clinicopathologic features and related Akt/mTOR, STAT3, ERK, cyclin D1, and PD-L1 expression
| Autor: | Cheol Lee, Minji Kim, Soyun Cho, Ji Ung Park, Sun Young Park, Jeong Hwan Park, Eui Cheol Jeong, Euno Choi, Mee Soo Chang |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male MAPK/ERK pathway Skin Neoplasms Databases Factual MAP Kinase Signaling System Dermatology Risk Assessment B7-H1 Antigen Metastasis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Cyclin D1 Republic of Korea Biomarkers Tumor medicine Dermatofibrosarcoma protuberans Humans Neoplasm Invasiveness Protein kinase B PI3K/AKT/mTOR pathway Aged Neoplasm Staging Cyclin business.industry TOR Serine-Threonine Kinases Biopsy Needle Dermatofibrosarcoma Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Gene Expression Regulation Neoplastic Oncogene Protein v-akt 030220 oncology & carcinogenesis Cancer research Female Neoplasm Recurrence Local business |
| Zdroj: | Journal of the American Academy of Dermatology. 79:843-852 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2018.05.016 |
| Popis: | Background Little is known regarding oncoproteins other than platelet-derived growth factor subunit B in dermatofibrosarcoma protuberans (DFSP). Moreover, the risk factors for worse prognosis are controversial. Objective We sought to determine the clinicopathologic features and key factors for adverse outcome in DFSP, including the implication of expression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT3), extracellular signal regulated kinase (ERK), cyclin D1, and programmed death ligand 1 (PD-L1). Methods Clinicopathologic and immunohistochemical analyses were performed for 44 DFSPs having wide local excision and 92 dermatofibromas as controls. Results Compared with the 35 nonrecurrent DFSPs, the 9 recurrent DFSPs exhibited larger tumor size, deeper invasion beyond the subcutis, and more diverse histologic subtype. The fibrosarcomatous subtype revealed frequent mitotic figures and a high cyclin D1–positive index. The 2 metastatic DFSPs (1 each of the fibrosarcomatous and myxoid subtypes) demonstrated 4 and 11 instances of local recurrence, respectively, as well as larger tumor size, deeper invasion beyond the subcutis, and high expression of cyclin D1. Expression of Akt/mTOR, STAT3, ERK, and PD-L1 ranged from none or low in the primary skin lesions to high in the corresponding metastatic sites. Akt/mTOR and ERK were expressed more frequently in DFSP than in dermatofibroma. Limitations Lack of information on patients before hospital evaluation. Conclusion Complex factors beyond fibrosarcomatous subtype may portend local recurrence or metastasis. Akt/mTOR, STAT3, ERK, and PD-L1 may be associated with development and/or progression of DFSP. |
| Databáze: | OpenAIRE |
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