Hemodialysis reduces plasma apolipoprotein C-I concentration making VLDL a better substrate for lipoprotein lipase
| Autor: | David Masson, Philippe Gambert, Guillaume Dautin, Laurent Lagrost, J.-P. Pais de Barros, Z. Soltani, Thomas Gautier, Didier Ducloux |
|---|---|
| Přispěvatelé: | Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Centre d'hémodialyse (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Service de Néphrologie et Urologie, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC ( HOTE GREFFON ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Université de Franche-Comté ( UFC ), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service d'urologie, andrologie et transplantation rénale, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Saas, Philippe, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Very low-density lipoprotein Apolipoprotein C Apolipoprotein B Cholesterol VLDL MESH: Apolipoprotein C-I MESH : Aged 030204 cardiovascular system & hematology chemistry.chemical_compound 0302 clinical medicine MESH: Cholesterol VLDL [ SDV.IMM ] Life Sciences [q-bio]/Immunology MESH: Renal Dialysis MESH : Female Intermediate-density lipoprotein MESH: Aged 0303 health sciences Lipoprotein lipase hemodialysis MESH: Middle Aged biology Middle Aged MESH : Renal Dialysis Biochemistry Nephrology MESH: Cholesterol Ester Transfer Proteins MESH: Kidney Failure Chronic MESH : Cholesterol Ester Transfer Proteins MESH : Cholesterol HDL [SDV.IMM]Life Sciences [q-bio]/Immunology Apolipoprotein L Female lipids (amino acids peptides and proteins) MESH : Apolipoprotein C-I MESH : Lipoprotein Lipase MESH: Cholesterol HDL MESH: Lipoprotein Lipase medicine.medical_specialty [SDV.IMM] Life Sciences [q-bio]/Immunology apolipoprotein C-I MESH : Male cholesteryl ester transfer protein lipoprotein lipase MESH : Kidney Failure Chronic 03 medical and health sciences Renal Dialysis Internal medicine medicine Humans MESH : Middle Aged MESH : Cholesterol VLDL 030304 developmental biology Aged MESH: Humans Cholesterol Cholesterol HDL MESH : Humans nutritional and metabolic diseases MESH: Male Cholesterol Ester Transfer Proteins Endocrinology chemistry biology.protein Kidney Failure Chronic MESH: Female Lipoprotein |
| Zdroj: | Kidney International Kidney International, Nature Publishing Group, 2007, 72 (7), pp.871-8. 〈10.1038/sj.ki.5002449〉 Kidney International, Nature Publishing Group, 2007, 72 (7), pp.871-8. ⟨10.1038/sj.ki.5002449⟩ |
| ISSN: | 0085-2538 1523-1755 |
| DOI: | 10.1038/sj.ki.5002449〉 |
| Popis: | International audience; Apolipoprotein Cs (apoC-1, apoC-II, and apoC-III) are lipoprotein components that have regulatory effects on enzymes involved in lipoprotein metabolism. Owing to their low molecular weights, apoCs can adsorb onto and/or pass through dialysis membranes. Our study determines the consequence of hemodialysis (HD) on plasma concentrations of apoCs and on the activities of enzymes modulated by apoCs. Plasma samples were collected from 28 patients with chronic renal failure before and after HD. Plasma apoC-II levels were unchanged, whereas apoC-III levels were slightly decreased in post-dialysis plasmas. The apoC-I content was markedly reduced during HD. This was due to a significant decrease in the apoC-I content of very low-density lipoprotein (VLDL), whereas the apoC-I content of high-density lipoprotein (HDL) was unchanged. Although HDL bound apoC-I is thought to inhibit cholesterol ester transfer protein, no change in the ability of pre- and post-dialysis VLDL to interact with the transfer protein were observed. Complementary experiments confirmed that VLDL-bound apoC-I has no transfer protein inhibitory potential. In contrast, an increase in the ability of post-dialysis apoC-I-poor VLDL to act as substrate for lipoprotein lipase (LPL) was found compared to pre-dialysis VLDL. Our study shows that apoC-I losses during HD might be beneficial by improving the ability of VLDL to be a substrate for LPL thus improving plasma triglyceride metabolism. |
| Databáze: | OpenAIRE |
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