Age-specific prevalence of anti-Pgp3 antibodies and severe conjunctival scarring in the Solomon Islands
| Autor: | Anthony W. Solomon, Robert Butcher, Matthew J. Burton, Oliver Sokana, Roberts Ch, Diana L. Martin, Denise Mabey, Kelvin Jack |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030231 tropical medicine Population Azithromycin medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Epidemiology medicine education Trichiasis 030304 developmental biology 0303 health sciences education.field_of_study biology business.industry medicine.disease Age specific Dermatology 3. Good health biology.protein Antibody CONJUNCTIVAL SCARRING Chlamydia trachomatis business medicine.drug |
| DOI: | 10.1101/141135 |
| Popis: | BackgroundTrachomatous trichiasis (TT) and ocularChlamydia trachomatis (Ct)infection in the Solomon Islands are scarce, whereas trachomatous inflammation–follicular (TF) is prevalent.MethodsWe enrolled 1511 people aged ≥1 year from randomly selected households in 13 villages in which >10% of the population had TF prior to a single round of azithromycin MDA undertaken six months previously. Blood was collected from people of all ages to be screened for anti-Pgp3 antibodies. Photographs were collected from people of all ages for analysis of scarring severity.ResultsConjunctival scars were visible in 13.1% of photographs. Mild (pConclusionsSigns of trachoma are common in the Solomon Islands but occur frequently in individuals who have no serological evidence of prior ocular infection withCt.WHO recommendations for directing MDA provision based on signs alone may not be suitable in this context. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|