Effects of multiple inherited and acquired thrombophilia on outcomes of in-vitro fertilization
| Autor: | Gian Mario Tiboni, Adalisa Ponzano, Marcello Di Nisio, Maria Domenica Guglielmi, Anne Wilhelmina Saskia Rutjes, Ettore Porreca |
|---|---|
| Přispěvatelé: | Vascular Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pregnancy test
Adult medicine.medical_specialty Reproductive Techniques Assisted medicine.medical_treatment Fertilization in Vitro 030204 cardiovascular system & hematology Abortion Thrombophilia 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Assisted reproductive technique Live birth Prospective studies Spontaneous abortion Hematology Humans Prospective cohort study 610 Medicine & health Lupus anticoagulant 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Obstetrics Pregnancy Outcome Odds ratio medicine.disease Abortion Spontaneous Female business 360 Social problems & social services |
| Zdroj: | Thrombosis research, 167, 26-31. Elsevier Limited |
| ISSN: | 0049-3848 |
| Popis: | Introduction The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. Materials and methods Consecutive women scheduled for IVF were eligible. The primary study outcome was live birth. Secondary outcomes included spontaneous abortion, clinical pregnancy, and symptomatic venous thromboembolism. Results 687 women with a mean age of 34.6 (±3.2) years were included. Overall, 22 women (3.2%) had two or more thrombophilic defects. The probability of live birth was not statistically significantly different between women with ≥2 thrombophilia (odds ratio [OR] 0.62; 95% confidence interval [CI], 0.18 to 2.11) or ≥1 thrombophilia (OR 0.67;95% CI, 0.41 to 1.09) and women without any thrombophilia. None of the individual inherited thrombophilia nor positivity to antiphospholipid antibodies or lupus anticoagulant were associated with live birth. Single positivity for lupus anticoagulant carried a more than threefold higher risk of abortion (OR 3.74; 95% CI, 1.30 to 10.75). There were no statistically significant associations between individual or multiple thrombophilic defects and clinical pregnancy or pregnancy test results. No woman had a history of venous thromboembolism and none developed a thrombotic event during the study. Conclusions In women undergoing IVF, the presence of two or more thrombophilic defects was rare and showed no statistically significant associations with IVF outcomes. |
| Databáze: | OpenAIRE |
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