Association of − 757T > C polymorphism of C-reactive protein gene with chronic periodontitis of South Indian population
| Autor: | Sreekanth M Selvaraj, Bagavad Gita Jayaraman, Adaikkalam Vellaichamy, Sinthuja Gurumoorthy, Judith J Christina |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Genotype Immunology India Single-nucleotide polymorphism Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Polymorphism (computer science) Odds Ratio Humans Medicine Genetic Predisposition to Disease Allele Aged Pharmacology Periodontitis biology business.industry C-reactive protein Middle Aged medicine.disease Chronic periodontitis C-Reactive Protein 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Chronic Periodontitis biology.protein Gene polymorphism business |
| Zdroj: | Inflammation Research. 68:347-349 |
| ISSN: | 1420-908X 1023-3830 |
| DOI: | 10.1007/s00011-019-01230-2 |
| Popis: | CRP gene polymorphism is common in inflammatory diseases, but such association has not been reported in periodontitis. Our objective was to interrogate SNPs of crp in chronic periodontitis in a case–control manner. DNAs were extracted from mouthwash samples of 116 volunteers using salting-out method. Selected 12 5′UTR SNPs of crp were genotyped using ARMS–PCR. TC genotype of − 757T > C polymorphism (rs3093059) showed protective association (OR— 0.29, 95%CI—0.12–0.68, and p—0.004), and wild type − 757TT showed susceptible association with a p value of 0.008 (OR—3.09, 95%CI—1.33–7.15). The observation of protective and susceptible association of crp − 757T > C polymorphism may be useful for better management and prophylaxis of periodontitis. |
| Databáze: | OpenAIRE |
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