Functional Recovery in Hemiparkinsonian Primates Transplanted with Polymer-Encapsulated PC12 Cells
| Autor: | Patrick Aebischer, Armando P. Signore, Roxanne L. Timpson, Moses Goddard |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Transplantation Heterologous Adrenal Gland Neoplasms Heterologous Capsules Pheochromocytoma Striatum PC12 Cells Immune system Developmental Neuroscience Dopaminergic Cell Animals Medicine Parkinson Disease Secondary Tyrosine hydroxylase business.industry Rats Cell biology Transplantation Macaca fascicularis medicine.anatomical_structure Neurology 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Adrenal Medulla Cell culture Cattle business Adrenal medulla Neoplasm Transplantation |
| Zdroj: | Experimental Neurology. 126:151-158 |
| ISSN: | 0014-4886 |
| DOI: | 10.1006/exnr.1994.1053 |
| Popis: | Cross-species neural grafting of cell lines immunoisolated by a permselective polymer membrane represents a promising source of neuroactive molecules for the treatment of neurodegenerative diseases. Utilization of a cell line of xenogeneic origin is advantageous since the transplanted cells will be rejected by the host immune system in case of breakage of the immunoisolating envelope. Polymer-encapsulated PC12 cells, a dopaminergic cell line derived from a rat pheochromocytoma, were transplanted in five Macaca fascicularis monkeys which had been previously rendered hemiparkinsonian by a unilateral carotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Well-preserved, tyrosine hydroxylase positive encapsulated PC12 cells were observed in the lesioned striatum for up to 5 months after implantation. Four out of five monkeys which received polymer-encapsulated PC12 cells showed significant behavioral improvement, whereas three monkeys implanted with either encapsulated bovine chromaffin cells or empty polymer envelopes showed no amelioration. |
| Databáze: | OpenAIRE |
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