Dexanabinol prevents development of vasospasm in the rat femoral artery model
| Autor: | Amselem Shimon, Ramazan Durmaz, Cengiz Bayçu, Varol Sahinturk, Kismet Civi, Hilmi Ozden, Ahmet Ozsandik |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Dexanabinol medicine.medical_specialty Subarachnoid hemorrhage Urology Apoptosis Femoral artery chemistry.chemical_compound Subarachnoid Hemorrhage Traumatic Microscopy Electron Transmission medicine.artery In Situ Nick-End Labeling Leukocytes Endothelial cell apoptosis Animals Vasospasm Intracranial Medicine Dronabinol Rats Wistar business.industry Endothelial Cells Vasospasm General Medicine medicine.disease Immunohistochemistry Rats Femoral Artery Neuroprotective Agents chemistry Vessel morphology Anesthesia Nerve Degeneration Surgery Neurology (clinical) business Wall thickness |
| Zdroj: | Neurosurgical Review. 31:215-223 |
| ISSN: | 1437-2320 0344-5607 |
| DOI: | 10.1007/s10143-007-0119-z |
| Popis: | We postulated that a multi-potential agent such as dexanabinol may prevent the development of vasospasm after subarachnoid hemorrhage. We tested the effect of dexanabinol (10 mg/kg) on established vasospasm in a rat femoral artery model. Dexanabinol was given as single or repeated doses. On the 7th day after blood application, vessels were prepared for transmission electron microscopy studies, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling staining, and studying vessel morphology including luminal area and wall thickness. Application of blood to femoral artery caused a significant narrowing of luminal area (p0.05) and decreased radial wall thickness significantly compared to hemorrhage (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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