Electrophysiological Characterization of Nicotine-Induced Excitation of Dopaminergic Neurons in the Rat Substantia Nigra
| Autor: | Norio Sakai, Takahiro Seki, Hiroaki Matsubayashi, Taku Amano, Masashi Sasa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Nicotine
Patch-Clamp Techniques Dopamine Substantia nigra Nicotinic Antagonists Striatum Receptors Nicotinic Membrane Potentials medicine Animals Nicotinic Agonists Patch clamp Nicotinic Antagonist Neurons Pharmacology Dose-Response Relationship Drug Chemistry Dopaminergic lcsh:RM1-950 Dihydro-beta-Erythroidine Rats Receptors Neurotransmitter Electrophysiology Substantia Nigra Nicotinic agonist lcsh:Therapeutics. Pharmacology nervous system Molecular Medicine Neuroscience medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 93, Iss 2, Pp 143-148 (2003) |
| ISSN: | 1347-8613 |
| Popis: | The electrophysiological characteristics of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra was investigated using the whole-cell patch clamp technique under the voltage-clamp mode. Nicotine (0.01 - 100 microM) induced inward currents corresponding to nicotine-induced depolarization with an increase in firing in a dose-dependent manner. This current was inhibited by dihydro-beta-erythroidine, a selective antagonist for the alpha4beta2 type neuronal nicotinic receptor. Nicotine directly acts on postsynaptic alpha4beta2 type nicotinic receptors and induces inward currents, resulting in excitation of dopaminergic neurons in the substantia nigra and subsequent enhancement of dopamine release in the corpus striatum. |
| Databáze: | OpenAIRE |
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