Elimination of spatial interference in PRESS-localized editing spectroscopy
| Autor: | Karl Young, Lana G. Kaiser, Gerald B. Matson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Brain Chemistry
Artifact (error) Magnetic Resonance Spectroscopy Phantoms Imaging Chemistry Improved method Signal Imaging phantom Spectral separation Reduction (complexity) Nuclear magnetic resonance Interference (communication) Humans Radiology Nuclear Medicine and imaging Artifacts Spectroscopy gamma-Aminobutyric Acid |
| Zdroj: | Magnetic Resonance in Medicine. 58:813-818 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.21407 |
| Popis: | Unambiguous detection of gamma-amino butyric acid (GABA) in the human brain is hindered by low concentration and spectral overlap with other metabolites. The popular MEGA-PRESS (PRESS: point-resolved spectroscopic sequence) method allows spectral separation of GABA from other metabolites, but suffers from a significant signal-to-noise ratio (SNR) reduction due to the 4-compartment artifact. An alternative PRESS localization technique (PRESS+4) was investigated and compared to MEGA-PRESS using numerical simulations, phantom, and in vivo experiments. It was shown that while the MEGA-PRESS method suffers significant signal loss ( approximately equal 20% for the difference spectrum), GABA signal intensity in PRESS+4 is reduced by only 2% compared to the nonlocalized condition at 4T. The improved method retains important features of the popular MEGA-PRESS such as additional water suppression and macromolecular elimination as demonstrated in human brain experiments. This method is not limited to GABA J-difference editing, but can be applied in any PRESS-based experiments. It should prove particularly useful at higher field, where the 4-compartment artifact is especially detrimental. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text