Emergence of MRSA of unknown origin in the Netherlands

Autor: W.J.B. van Wamel, A. Haenen, Jan Hendrik Richardus, Margreet C. Vos, Aura Timen, P. J. van den Broek, H. A. Verbrugh, Aimée Tjon-A-Tsien, M. A. B. van der Sande, W. S. N. Lekkerkerk, A. Groenheide, N. van de Sande-Bruinsma, A J de Neeling
Přispěvatelé: Medical Microbiology & Infectious Diseases, Public Health
Rok vydání: 2011
Předmět:
Male
Veterinary medicine
Community
Skin infection
medicine.disease_cause
Communicable Diseases
Emerging
Risk groups
Leukocidins
Epidemiology
prevention and control
risk
Netherlands
Aged
80 and over
Cross Infection
Transmission (medicine)
General Medicine
Middle Aged
Staphylococcal Infections
Panton-Valentine leukocidin
Community-Acquired Infections
Infectious Diseases
surveillance
epidemiology
Female
policy
Microbiology (medical)
Adult
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty
Adolescent
Genotype
Bacterial Toxins
Exotoxins
Young Adult
Internal medicine
medicine
Humans
Aged
business.industry
the Netherlands
biochemical phenomena
metabolism
and nutrition
medicine.disease
bacterial infections and mycoses
Methicillin-resistant Staphylococcus aureus
livestock
Molecular Typing
Carriage
Relative risk
Panton–Valentine leukocidin
business
Zdroj: Clinical Microbiology and Infection, 18(7), 656-661. Elsevier Ltd.
Clinical Microbiology and Infection
ISSN: 1469-0691
1198-743X
Popis: Clin Microbiol Infect 2012; 18: 656661 Abstract The Netherlands is known for its low methicillin-resistant Staphylococcus aureus (MRSA) prevalence. Yet MRSA with no link to established Dutch risk factors for acquisition, MRSA of unknown origin (MUO), has now emerged and hampers early detection and control by active screening upon hospital admittance. We assessed the magnitude of the problem and determined the differences between MUO and MRSA of known origin (MKO) for CC398 and non-CC398. National MRSA Surveillance data (20082009) were analysed for epidemiological determinants and genotypic characteristics (PantonValentine leukocidin, spa). A quarter (24%) of the 5545 MRSA isolates registered were MUO, i.e. not from defined risk groups. There are two genotypic MUO groups: CC398 MUO (352; 26%) and non-CC398 MUO (998; 74%). CC398 MUO needs further investigation because it could suggest spread, not by direct contact with livestock (pigs, veal calves), but through the community. Non-CC398 MUO is less likely to be from a nursing home than non-CC398 MKO (relative risk 0.55; 95% CI 0.420.72) and PantonValentine leukocidin positivity was more frequent in non-CC398 MUO than MKO (relative risk 1.19; 95% CI 1.111.29). Exact transmission routes and risk factors for non-CC398 as CC398 MUO remain undefined.
Databáze: OpenAIRE
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