Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns
| Autor: | Nathalie Doerflinger, Frantz Bouhallier, Elmer Guzman, Bian Wu, Hongjun Zhou, Xiaolu A. Cambronne, Richard H. Goodman, Colette Dehay, C. Huissoud, Danielle S. Bassett, Neha Rani, Marion Betizeau, Mary Luz Arcila, Ugo Borello, Kenneth S. Kosik |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Evolution
Neuroscience(all) Neurogenesis Subventricular zone Biology Macaque Article Evolution Molecular Cortex (anatomy) biology.animal microRNA medicine Animals Psychology Visual Cortex Neurons Regulation of gene expression Neurology & Neurosurgery General Neuroscience Cell Cycle Neurosciences Molecular Embryonic stem cell Cell biology MicroRNAs medicine.anatomical_structure Visual cortex Gene Expression Regulation Macaca Female Cognitive Sciences Neuroscience |
| Zdroj: | Arcila, ML; Betizeau, M; Cambronne, XA; Guzman, E; Doerflinger, N; Bouhallier, F; et al.(2014). Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns. Neuron, 81(6), 1255-1262. doi: 10.1016/j.neuron.2014.01.017. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/51r3p50c Neuron, vol 81, iss 6 |
| DOI: | 10.1016/j.neuron.2014.01.017. |
| Popis: | Major nonprimate-primate differences in corticogenesis include the dimensions, precursor lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of laser-dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including ventricular zone (VZ) and outer and inner subcompartments of the outer subventricular zone (OSVZ) in area 17 displayed unique miRNA profiles. miRNAs present in primate, but absent in rodent, contributed disproportionately to the differential expression between GZ subregions. Prominent among the validated targets of these miRNAs were cell-cycle and neurogenesis regulators. Coevolution between the emergent miRNAs and their targets suggested that novel miRNAs became integrated into ancient gene circuitry to exert additional control over proliferation. We conclude that multiple cell-cycle regulatory events contribute to the emergence of primate-specific cortical features, including the OSVZ, generated enlarged supragranular layers, largely responsible for the increased primate cortex computational abilities. © 2014 Elsevier Inc. |
| Databáze: | OpenAIRE |
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