The relationship between obesity, hemoglobin A1c and the severity of COVID-19 at an urban tertiary care center in New York City: a retrospective cohort study
Autor: | Zachary L Lodato, Stephan Kamholz, Sharad Oli, Thanunthorn Suban Na Ayutthaya, Sumrah A Syed, Kunzah Syed, Lawrence Wolf, Michael Silver, Kavish Singh, Sanchit V. Kundal, Vladimir Rozvadovskiy, Shanado Williams, Gurchetan Randhawa |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty ARDS medicine.medical_treatment lcsh:Medicine diabetes & endocrinology Comorbidity 030204 cardiovascular system & hematology Risk Assessment Body Mass Index 03 medical and health sciences Random Allocation 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus Medicine Humans Renal replacement therapy Obesity Mortality 030304 developmental biology Retrospective Studies Glycated Hemoglobin 0303 health sciences business.industry Septic shock SARS-CoV-2 lcsh:R COVID-19 Retrospective cohort study General Medicine Acute Kidney Injury Middle Aged medicine.disease Respiration Artificial internal medicine Outcome and Process Assessment Health Care Infectious Diseases Cohort Female New York City business Body mass index |
Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 1 (2021) |
ISSN: | 2044-6055 |
Popis: | ObjectivesTo determine if obesity and diabetes are risk factors for severe outcomes in COVID-19 and to compare patient outcomes in those two conditions.DesignRetrospective cohort study.SettingUrban tertiary care center in New York City.Participants302 patients admitted in an inpatient setting, ≥18 years old, with a laboratory-confirmed diagnosis of COVID-19 via nasal PCR swab were randomly selected. Patients were separated into two cohorts based on their body mass index and hemoglobin A1c. 150 patients were placed in the non-obese, non-diabetic cohort and 152 patients were placed in the corresponding cohort (obesity alone, obesity and diabetes, and diabetes alone).MeasurementsPrimary outcomes were development of acute kidney injury, commencement of renal replacement therapy, aminotransferase elevation, troponin elevation, lactic acidosis, development of septic shock, use of vasopressors, presence of acute respiratory distress syndrome (ARDS) and intubation. The secondary outcomes were length of stay in days and mortality.ResultsPatients with obesity and/or diabetes were more likely to develop ARDS (79 patients vs 57 patients, pConclusionsIn patients hospitalised with COVID-19, those with obesity and/or diabetes were more likely to suffer severe complications, but had negligible differences in mortality. This highlights the importance of close monitoring of patients with these conditions and additional areas of research needed to explain the mortality findings. |
Databáze: | OpenAIRE |
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