Atrial fibrillation is a risk marker for worse in-hospital and long-term outcome in patients with peripheral artery disease
| Autor: | Matthias Meyborg, Nasser M. Malyar, Holger Reinecke, Michael Unrath, Eva Freisinger, Kristina Wasmer, Günter Breithardt, Julia Köbe, Lars Eckardt |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Disease Risk Assessment Coronary artery disease Peripheral Arterial Disease Risk Factors Cause of Death Diabetes mellitus Internal medicine Atrial Fibrillation Prevalence medicine Humans Hospital Mortality Aged Retrospective Studies Inpatients Vascular disease business.industry Atrial fibrillation Critical limb ischemia Prognosis medicine.disease body regions Heart failure Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies Kidney disease |
| Zdroj: | International Journal of Cardiology. 199:223-228 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2015.06.094 |
| Popis: | To investigate the relevance of atrial fibrillation or flutter (AF) for outcome of patients who are hospitalized for peripheral artery disease (PAD) and/or critical limb ischemia (CLI).We compared baseline data, co-morbidities, procedural data as well as in-hospital and long-term outcome of 41,882 patients who were hospitalized with PAD or CLI between 2009 and 2011 according to whether they did or did not have atrial fibrillation/flutter. Follow-up was available until December 2012. Of these, 5622 patients (13.4%) had AF. AF patients were significantly older (78±9 vs. 70±11years) and had significantly more comorbidities, such as diabetes (40.8 vs. 31.1%), chronic kidney disease (40.1 vs. 19.0%), coronary artery disease (38.0 vs. 23.0%) and chronic heart failure (26.9 vs. 7.2%, each p0.001). They had more advanced PAD as shown by higher Rutherford classes. In-hospital complications including acute renal failure, myocardial infarction, stroke sepsis and death occurred significantly more often (each p0.001). Duration of hospital stay was significantly longer and costs were markedly higher in patients with AF (each p0.001). Using multivariate Cox regression analyses regarding long-term outcomes, AF was an independent predictor for death (HRR 1.46; 95% CI 1.39-1.52, p0.001), ischemic stroke (HRR 1.63; 95% CI 1.44-1.85) and amputation (HRR 1.14; 95% CI 1.07-1.21).Presence of AF in patients admitted for PAD and CLI is associated with worse in-hospital and long-term outcome than in patients without AF. This effect was independent of numerous other comorbidities and stage of vascular disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect