Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal
| Autor: | Roberta Monteiro Incrocci, Manoel Jorge Nobre, Franciely Paliarin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Inferior colliculus Male Psychosis Microinjections Prefrontal Cortex Sensory system Stimulation Neurotransmission Toxicology Receptors N-Methyl-D-Aspartate 03 medical and health sciences 0302 clinical medicine Dorsal raphe nucleus medicine Animals Rats Wistar Clozapine business.industry General Neuroscience Glutamate receptor medicine.disease Rats Substance Withdrawal Syndrome 030104 developmental biology Evoked Potentials Auditory NMDA receptor Ketamine Serotonin Antagonists business Neuroscience Excitatory Amino Acid Antagonists 030217 neurology & neurosurgery |
| Zdroj: | Neurotoxicology. 69 |
| ISSN: | 1872-9711 |
| Popis: | Ketamine (KET) is a non-competitive N-Methyl-d-aspartate (NMDA) receptors antagonist that intensifies sensory experiences, prompts hallucinations and delusions, exacerbates previously installed psychosis and disrupts physiological evoked potentials (AEPs). Pharmacologically, KET stimulates glutamate efflux in the medial prefrontal cortex, mainly in the prelimbic (PrL) sub-region. Efferences from this region exert a top-down regulatory control of bottom-up sensory processes either directly or indirectly. In the midbrain, the central nucleus of the inferior colliculus (CIC) plays a fundamental role in the processing of auditory ascending information related to sound localization, sensorimotor gating, and preattentive event-related potentials. Auditory hallucinations elicited during a psychotic outbreak are accompanied by CIC neural activation. Thus, it is possible that NMDA-mediated glutamate neurotransmission in the PrL indirectly modulates CIC neuronal firing. The aim of the present study was to assess the effects of KET on the latency and amplitude of AEPs elicited in the CIC of rats tested during KET effects and following withdrawal from the chronic administration. Changes on emotionally induced by KET treatment were evaluated with the use of the elevated zero maze (EZM). Unlike typical neuroleptics, the atypical antipsychotic clozapine (CLZ) potently blocks the disruption of the sensorimotor gating induced by NMDA antagonists. Therefore, the effects of KET withdrawal on AEPs were challenged with a systemic injection of CLZ. In addition, we further investigated the role of NMDA receptors of the PrL on the AEPs expression recorded in the CIC through intra-PrL infusions of NMDA itself. Our results showed that the processing of sensory information in the CIC is under indirect control of PrL. These data suggest that the long-term KET treatment disrupts the collicular auditory field potentials, possibly through influencing PrL glutamate activity on intrinsic 5-HT mechanisms in the dorsal raphe and CIC. |
| Databáze: | OpenAIRE |
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