Treatment of the Schoenlein-Henoch Syndrome with Adrenocorticotrophic Hormone (A.C.T.H.) and Cortisone
| Autor: | M. G. Philpott, J. N. Briggs |
|---|---|
| Rok vydání: | 1953 |
| Předmět: |
medicine.medical_specialty
IgA Vasculitis Polyarteritis nodosa business.industry Incidence (epidemiology) Glomerulonephritis Articles Adrenocorticotropic hormone medicine.disease Dermatology Cortisone Purpura Adrenocorticotropic Hormone Pediatrics Perinatology and Child Health Immunology medicine Humans Rheumatic fever medicine.symptom business Nephritis medicine.drug |
| Zdroj: | Archives of Disease in Childhood. 28:57-60 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.28.137.57 |
| Popis: | It has been shown that a relationship exists between the Schoenlein-Henoch syndrome and diseases such as acute nephritis, rheumatic fever and polyarteritis nodosa (Gairdner, 1948). In view of this relationship, it seemed reasonable to try the effect of adrenocorticotrophic hormone (A.C.T.H.) and cortisone on the course of this disease. It was hoped also that these hormones might reduce the incidence of glomerulonephritis, which was found by Philpott (1952) in 47 5% of 40 cases in children studied, and which is considered the most dangerous complicating feature of this syndrome. Only a few reports have appeared in the literature on the treatment of the Schoenlein-Henoch syndrome with A.C.T.H. and cortisone. Stefanini, Roy, Zannos and Dameshek (1950) treated one case with A.C.T.H. Although this patient's general condition improved remarkably, there were further attacks of purpura while the patient was being treated and a relapse of all symptoms occurred when it was stopped. Nephritis, which was present before starting the A.C.T.H., deteriorated while under treatment. Woolley (1952) reported a case treated with A.C.T.H. in which further symptoms occurred while under treatment and pre-existing nephritis deteriorated. Kugelmass (1951) reported four cases treated with cortisone and was enthusiastic about its value. He did not state, however, how frequent or how complete were the urinalyses in these cases, and did not make clear how long these patients were under surveillance. Kugelmass admitted that 'mild manifestations' might continue for weeks after the withdrawal of the drugs. We have treated nine children with the SchoenleinHenoch syndrome with A.C.T.H. or cortisone or both. The results are presented, two cases being reported in full and summaries given of the remain |
| Databáze: | OpenAIRE |
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