Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer
| Autor: | Jian-Qiu Jin, Zhenghe Zhang, Weian Zhang, Yucheng Zhu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Porphyrins
02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Polymerization chemistry.chemical_compound Mice Neoplasms Tetraphenylporphyrin polycyclic compounds Copolymer Animals Humans Organosilicon Compounds Maleimide Photosensitizing Agents Singlet Oxygen Singlet oxygen 010405 organic chemistry Chain transfer General Chemistry General Medicine 021001 nanoscience & nanotechnology Combinatorial chemistry Porphyrin Silsesquioxane 0104 chemical sciences chemistry Photochemotherapy A549 Cells Nanoparticles 0210 nano-technology |
| Zdroj: | Angewandte Chemie. 130:16592-16596 |
| ISSN: | 0044-8249 |
| Popis: | Aggregation-induced quenching (AIQ) of photosensitizers greatly reduces the quantum yield of singlet oxygen generation and mitigates the efficacy of photodynamic therapy (PDT). We have prepared an alternating copolymer starting from 4-vinylbenzyl-terminated tetraphenylporphyrin (VBTPP) and maleimide isobutyl polyhedral oligomeric silsesquioxane (MIPOSS), via alternating reversible addition-fragmentation chain transfer (RAFT) polymerization. Porphyrin and POSS are installed on the amphiphilic block copolymers backbone in an alternating fashion and POSS completely inhibits the aggregation of porphyrin units via stacking. The amphiphilic block copolymer can self-assemble into nanoparticles and its application in PDT treatment was tested. These porphyrin-containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, providing a novel strategy to enhance the PDT efficacy. |
| Databáze: | OpenAIRE |
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