Growth hormone, insulin-like growth factor-I and insulin-like growth factor binding protein-3 are regulated differently in small-for-gestational-age and appropriate-for-gestational-age neonates
| Autor: | Sophie Laborie, J. Tricoire, Hélène Grandjean, A. Cance-Rouzaud, M.-T. Tauber, P. Rochiccioli, E. Bieth, M. Rolland |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Birth weight Biology Growth hormone Insulin-like growth factor-binding protein Insulin-like growth factor Internal medicine medicine Humans Insulin-Like Growth Factor I Fetus Appropriate for gestational age Human Growth Hormone Growth factor Infant Newborn medicine.disease Body Height Endocrinology Insulin-Like Growth Factor Binding Protein 3 Pediatrics Perinatology and Child Health Infant Small for Gestational Age biology.protein Small for gestational age Female Developmental Biology |
| Zdroj: | Biology of the neonate. 73(6) |
| ISSN: | 0006-3126 |
| Popis: | Growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) were measured in 90 neonates during the first 5 days of life. Twenty-six small-for-gestational-age (SGA) neonates were compared with 64 appropriate-for-gestational-age (AGA) neonates. There were no differences in nutritional status between the 2 groups. Mean GH levels were significantly higher in the SGA group (53.4 ± 30.8 vs. 39.9 ± 23.3 µg/l; p < 0.05). In both groups GH levels correlated with birth weight (expressed as SDS) but not with gestational age. IGF-I levels were significantly lower in SGA neonates (6.6 ± 4.0 vs. 11.7 ± 8.2 ng/ml; p < 0.01). In SGA neonates with short stature, IGF-I levels were lower and GH levels were higher than in normal stature SGA neonates. IGFBP-3 levels were significantly lower in SGA neonates than in AGA neonates (0.72 ± 0.40 vs. 0.98 ± 0.43 µg/l; p < 0.01). IGF-I and IGFBP-3 correlated with gestational age in AGA but not in SGA neonates and there was no correlation with birth weight in either group. Our data provide evidence for a graduation in the severity of impact of fetal ‘malnutrition’ on the somatotropic axis and on intrauterine growth. The most severe state (SGA with short stature) was associated with a GH-resistance syndrome, characterized by very low IGF-I levels and high GH levels. |
| Databáze: | OpenAIRE |
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