Evaluation of the Role of Umbilical Cord Serum and Autologous Serum Therapy in Reepithelialization After Keratoplasty: A Randomized Controlled Clinical Trial
| Autor: | Rasik B Vajpayee, Suneeta Mittal, Ritu Nagpal, Prafulla K. Maharana, Tushar Agarwal, Thirumurthy Velpandian, Neha Kamble, Namrata Sharma, Pooja Bandivadekar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Serum medicine.medical_specialty Visual acuity medicine.medical_treatment Visual Acuity law.invention Corneal Diseases 03 medical and health sciences 0302 clinical medicine Primary outcome Randomized controlled trial Re-Epithelialization law medicine Humans Prospective Studies Wound Healing business.industry Epithelium Corneal Treatment options Middle Aged Autologous serum Fetal Blood Surgery Clinical trial Ophthalmology Artificial tears 030104 developmental biology 030221 ophthalmology & optometry Female medicine.symptom business Keratoplasty Penetrating Umbilical Cord Serum |
| Zdroj: | Eyecontact lens. 43(5) |
| ISSN: | 1542-233X |
| Popis: | To evaluate the role of umbilical cord serum (UCS) and autologous serum (AS) therapy in reepithelialization of corneal graft after keratoplasty in a randomized controlled trial. A total of 105 eyes with epithelial defect (ED) after keratoplasty (penetrating keratoplasty—67 and anterior lamellar keratoplasty—38) on the first postoperative day were included in the study. The eyes were randomized into three groups: UCS (n=35), AS (n=35), and artificial tears (AT) (n=35). All patients received standard postoperative medical therapy. The primary outcome measure was time to epithelialization, and secondary outcome measures were best-corrected visual acuity and graft clarity. The ED healed completely in 103 eyes. The mean time for complete reepithelialization was 2.5±2.1, 3.1±2.2, and 4.5±1.4 days in UCS, AS, and AT groups, respectively. The mean percentage decrease in the size of the ED was significantly better in the UCS and AS groups as compared with the AT group (P=0.001). The rate of reepithelialization was comparable between the AS and UCS groups (P=0.3). On bivariate analysis, significant correlation was found between the mean size of postoperative ED, grade of the donor cornea (P=0.001), and the presence of preoperative ED (P=0.001). No complications were associated with the use of serum therapy. Most of the cases of postkeratoplasty corneal ED can be managed with AT only. The serum therapy (AS/UCS) helps in the faster reepithelialization of postkeratoplasty ED as compared with AT and may be considered as a treatment option for early epithelial healing. |
| Databáze: | OpenAIRE |
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