Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8
| Autor: | Banu Bayram, Stefanie Grimm, Patricia Huebbe, Gerald Rimbach, Tilman Grune, Beraat Özçelik, Sibylle Nikolai, Jan Frank |
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| Rok vydání: | 2012 |
| Předmět: |
Senescence
Proteasome Endopeptidase Complex Aging medicine.medical_specialty Antioxidant medicine.medical_treatment Inflammation Biology medicine.disease_cause Article Antioxidants Mice Internal medicine Gene expression medicine Animals Vitamin E General Medicine Ascorbic acid Mice Inbred C57BL Disease Models Animal Oxidative Stress Phenotype Endocrinology Ageing Immunology Female Geriatrics and Gerontology medicine.symptom Biomarkers Oxidative stress |
| Zdroj: | AGE. 35:1205-1217 |
| ISSN: | 1574-4647 0161-9152 |
| DOI: | 10.1007/s11357-012-9448-0 |
| Popis: | In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n = 10 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit beta-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and alpha-tocopherol in the liver. An age-dependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice. |
| Databáze: | OpenAIRE |
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