Food Restriction Causes Low Bone Strength and Microarchitectural Deterioration in Exercised Growing Male Rats
| Autor: | Naomi Omi, Takayuki Akimoto, Yuki Aikawa, Hideyuki Yamato, Ikuko Ezawa, Jong Hoon Park, Umon Agata, Michito Higano, Masaya Oda, Satoshi Hattori, Yoshiharu Nabekura |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Food intake Diet Reducing Bone density Medicine (miscellaneous) Physiology Running Rats Sprague-Dawley Bone strength Bone Density Physical Conditioning Animal Male rats Animals Medicine Femur Bone morphology Nutrition and Dietetics Tibia business.industry Body Weight X-Ray Microtomography Hormones Rats Food restriction Bone Diseases Metabolic Trabecular bone medicine.anatomical_structure Cortical bone Energy Intake Energy Metabolism business |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 60:35-42 |
| ISSN: | 1881-7742 0301-4800 |
| Popis: | The pathogenesis of bone disorders in young male athletes has not been well understood. We hypothesized that bone fragility is caused by low energy availability, due to insufficient food intake and excessive exercise energy expenditure in young male athletes. To examine this hypothesis, we investigated the influence of food restriction on bone strength and bone morphology in exercised growing male rats, using three-point bending test, dual-energy X-ray absormetry, and micro-computed tomography. Four-week-old male Sprague-Dawley rats were divided randomly into the following groups: the control (Con) group, exercise (Ex) group, food restriction (R) group, and food restriction plus exercise (REx) group after a 1-wk acclimatization period. Thirty-percent food restriction in the R and REx groups was carried out in comparison with that in the Con group. Voluntary running exercise was performed in the Ex and REx groups. The experimental period lasted 13 wk. At the endpoint of this experiment, the bone strength of the femurs and tibial BMD in the REx group were significantly lower than those in the Con group. Moreover, trabecular bone volume and cortical bone volume in the REx group were also significantly lower than those in the Con group. These findings indicate that food restriction causes low bone strength and microarchitectural deterioration in exercised growing male rats. |
| Databáze: | OpenAIRE |
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