Defective Antifungal Activity of Monocyte-Derived Macrophages from Human Immunodeficiency Virus-Infected Children against Aspergillus fumigatus
| Autor: | Thomas J. Walsh, Emmanuel Roilides, Philip A. Pizzo, Cassann Blake, Andrew Holmes |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Adolescent Phagocytosis HIV Infections In Vitro Techniques Neutropenia Aspergillosis Microbiology Aspergillus fumigatus Immunopathology medicine Humans Immunology and Allergy Macrophage Child Aspergillus biology Macrophages Monocyte Infant biology.organism_classification medicine.disease Infectious Diseases medicine.anatomical_structure Child Preschool Immunology |
| Zdroj: | Journal of Infectious Diseases. 168:1562-1565 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/168.6.1562 |
| Popis: | Invasive aspergillosis recently has been encountered in adults and children with human immunodeficiency virus (HIV) infection even without known risk factors, such as neutropenia or corticosteroid therapy. Macrophages play a significant role in the host defenses against Aspergillus organisms by ingesting conidia and preventing their germination to hyphae. The antifungal activity of peripheral blood monocyte-derived macrophages (MDM) from 19 HIV-infected children was compared with that of 16 normal controls. The phagocytic activity of patients' MDM, measured as percentage of phagocytosis, was significantly decreased compared with normal donors (P = .014). In addition, the inhibitory activity of MDM on germination of intracellular A. fumigatus conidia was significantly impaired in patients compared with normal controls (P = .016). There was no significant difference in the defects between patients with lower or higher CD4 lymphocyte counts. Impairment of antifungal activity of macrophages may contribute to the susceptibility of HIV-infected patients to aspergillosis. |
| Databáze: | OpenAIRE |
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