Diffusivity mapping of the ovaries: Variability of apparent diffusion and kurtosis variables over the menstrual cycle and influence of oral contraceptives
| Autor: | Judith Pantke, Hans-Ulrich Kauczor, Anna Mlynarska-Bujny, Joachim Rom, Tristan Anselm Kuder, Felix Christian Hasse, Theresa Mokry, Sebastian Bickelhaupt, Heinz Peter Schlemmer |
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| Rok vydání: | 2020 |
| Předmět: |
media_common.quotation_subject
Biomedical Engineering Biophysics Physiology Ovary 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Diffusion Kurtosis Imaging Menstrual cycle Menstrual Cycle media_common Both ovaries business.industry Repeated measures design medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Kurtosis Female business 030217 neurology & neurosurgery Contraceptives Oral |
| Zdroj: | Magnetic resonance imaging. 80 |
| ISSN: | 1873-5894 |
| Popis: | Purpose We aimed to investigate whether quantitative diffusivity variables of healthy ovaries vary during the menstrual cycle and to evaluate alterations in women using oral contraceptives (OC). Methods This prospective study (S-339/2016) included 30 healthy female volunteers, with (n = 15) and without (n = 15) intake of OC between 07/2017 and 09/2019. Participants underwent 3T diffusion-weighted MRI (b-values 0–2000 s/mm2) three times during a menstrual cycle (T1 = day 1–5; T2 = day 7–12; T3 = day 19–24). Both ovaries were manually three-dimensionally segmented on b = 1500 s/mm2; apparent diffusion coefficient (ADC) calculation and kurtosis fitting (Dapp, Kapp) were performed. Differences in ADC, Dapp and Kapp between time points and groups were compared using repeated measures ANOVA and t-test after Shapiro-Wilk and Brown-Forsythe test for normality and equal variance. Results In women with a natural menstrual cycle, ADC and kurtosis variables showed significant changes in ovaries with the dominant follicle between T1 vs T2 and T1 vs T3, whilst no differences were observed between T2 vs T3: ADC ± SD for T1 1.524 ± 0.160, T2 1.737 ± 0.160, and T3 1.747 ± 0.241 μm2/ms (p = 0.01 T2 vs T1; p = 1.0 T2 vs T3, p = 0.003 T3 vs T1); Dapp ± SD for T1 2.018 ± 0.140, T2 2.272 ± 0.189, and T3 2.230 ± 0.256 μm2/ms (p = 0.003 T2 vs T1, p = 1.0 T2 vs T3, p = 0.02 T3 vs T1); Kapp ± SD for T1 0.614 ± 0.0339, T2 0.546 ± 0.0637, and T3 0.529 ± 0.0567 (p Conclusion Physiological cycle-dependent changes in quantitative diffusivity variables of ovaries should be considered especially when interpreting radiomics analyses in reproductive women. |
| Databáze: | OpenAIRE |
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