183 CARTILAGE-SPECIFIC KNOCKOUT OF SITE-1 PROTEASE IN POSTNATAL MICE RESULTS IN AN ABNORMAL GROWTH PLATE WITH DISRUPTION OF HYPERTROPHIC CHONDROCYTE DIFFERENTIATION AND SUBSEQUENT CHONDRODYSPLASIA
| Autor: | S. Hayashi, Elizabeth DeLassus, Debabrata Patra, Linda J. Sandell |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Chemistry Cartilage Biomedical Engineering Site-1 protease SOX9 Hypoxia (medical) Cell biology Endocrinology medicine.anatomical_structure Downregulation and upregulation Rheumatology In vivo Internal medicine Hypertrophic chondrocyte medicine Orthopedics and Sports Medicine medicine.symptom Cartilage repair |
| Zdroj: | Osteoarthritis and Cartilage. 18 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/s1063-4584(10)60210-5 |
| Popis: | caused an upregulation of SOX9 and enhanced extracellular matrix protein production. Conclusions: Depletion of PHD2 resulted in greater HIF-2α levels, and therefore enhanced SOX9-induced cartilage matrix production compared to the levels normally found in hypoxia (1% oxygen) implying that PHD2 inhibition offers a novel means to promote the chondrocyte phenotype and enhance cartilage repair in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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