Risk Factors for Measles Virus Infection Among Adults During a Large Outbreak in Postelimination Era in Mongolia, 2015
| Autor: | Bettina Bankamp, Baigalmaa Jantsansengee, Gunregjav Nyamaa, Amarzaya Sarankhuu, Yoshihiro Takashima, Raydel Anderson, Roberta Pastore, Buyanjargal Yadamsuren, Kathleen Wannemuehler, James L. Goodson, Otgonbayar Dashpagma, Paul A. Rota, José E. Hagan, Mick N. Mulders |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Measles Vaccine 030231 tropical medicine National capital History 21st Century Measles Article Disease Outbreaks Measles virus Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Odds Ratio Humans Immunology and Allergy Medicine 030212 general & internal medicine Young adult Child biology business.industry Incidence Vaccination Age Factors Infant Newborn Infant Outbreak Mongolia Odds ratio medicine.disease biology.organism_classification Virology Confidence interval Infectious Diseases Case-Control Studies Child Preschool Population Surveillance Female Seasons High incidence business Demography |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | BACKGROUND. In 2015, a large nationwide measles outbreak occurred in Mongolia, with very high incidence in the capital city of Ulaanbaatar and among young adults. METHODS. We conducted an outbreak investigation including a matched case-control study of risk factors for laboratory-confirmed measles among young adults living in Ulaanbaatar. Young adults with laboratory-confirmed measles, living in the capital city of Ulaanbaatar, were matched with 2–3 neighborhood controls. Conditional logistic regression was used to estimate adjusted matched odds ratios (aMORs) for risk factors, with 95% confidence intervals. RESULTS. During March 1–September 30, 2015, 20 077 suspected measles cases were reported; 14 010 cases were confirmed. Independent risk factors for measles included being unvaccinated (adjusted matched odds ratio [aMOR] 2.0, P < .01), being a high school graduate without college education (aMOR 2.6, P < .01), remaining in Ulaanbaatar during the outbreak (aMOR 2.5, P < .01), exposure to an inpatient healthcare facility (aMOR 4.5 P < .01), and being born outside of Ulaanbaatar (aMOR 1.8, P = .02). CONCLUSIONS. This large, nationwide outbreak shortly after verification of elimination had high incidence among young adults, particularly those born outside the national capital. In addition, findings indicated that nosocomial transmission within health facilities helped amplify the outbreak. |
| Databáze: | OpenAIRE |
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