Effect of endothelin receptor antagonist on parathyroid gland growth, pth values and cell proliferation in azotemic rats
| Autor: | Ximena Jara, Andrea von Höveling, Arnold J. Felsenfeld, Sergio Mezzano, Aquiles Jara, M. Eugenia Burgos, Andrés Valdivieso |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Endothelin Receptor Antagonists
Male medicine.medical_specialty Parathyroid hormone Parathyroid Glands Rats Sprague-Dawley Internal medicine medicine Animals Antihypertensive Agents Cell Proliferation Uremia Transplantation Hyperparathyroidism Sulfonamides business.industry Antagonist Bosentan Parathyroid chief cell Hyperplasia medicine.disease Rats medicine.anatomical_structure Endocrinology Nephrology Parathyroid Hormone Phosphorus Dietary Parathyroid gland Endothelin receptor business medicine.drug |
| Zdroj: | NEPHROLOGY DIALYSIS TRANSPLANTATION Artículos CONICYT CONICYT Chile instacron:CONICYT |
| Popis: | Background. A variety of stimuli are involved in the pathogenesis of parathyroid gland hyperplasia in renal failure. Recently, it was shown that blocking the signal from the endothelin-1 (ET-1) receptor (ET A R/ET B R) by a non-selective receptor antagonist, bosentan, reduced parathyroid cell proliferation, parathyroid gland hyperplasia and parathyroid hormone (PTH) levels in normal rats on a calcium deficient diet. Our goal was to determine whether in 5/6 nephrectomized (NPX) rats with developing or established hyperparathyroidism, the endothelin receptor blocker, bosentan, reduced the increase in parathyroid cell proliferation, parathyroid gland hyperplasia and PTH values. Methods. High (HPD, 1.2%) or normal phosphorus diets (PD) (NPD, 0.6%) were given to 5/6 NPX rats for 15 days (NPX 15 ). In each dietary group, one-half the rats were given bosentan (B) i.p. 100mg/ kg/day. The four groups of rats were: (1) NPX 15 -1.2% P; (2) NPX 15 -1.2% P+B; (3) NPX 15 -0.6% P; and (4) NPX 15 -0.6% P+B. In a second study in which hyperparathyroidism was already established in 5/6 NPX rats fed a HPD for 15 days, rats were divided into two groups in which one group was maintained on a HPD and the other group was changed to very low PD (VLPD |
| Databáze: | OpenAIRE |
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