Association of Apolipoprotein E Polymorphism with Adipokines and Cardiovascular Disease Risk in Rheumatoid Arthritis Patients
| Autor: | Ching-Kun Chang, Chi-Chen Lin, Hsin-Hua Chen, Joung-Liang Lan, Der-Yuan Chen, Shih-Hsin Chang, Po-Ku Chen, Yi-Ming Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Apolipoprotein E medicine.medical_specialty Adipokine Gastroenterology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences apoE genotypes 0302 clinical medicine Insulin resistance Internal medicine Genotype medicine rheumatoid arthritis (RA) lcsh:Science adipokines Ecology Evolution Behavior and Systematics 030203 arthritis & rheumatology medicine.diagnostic_test Adiponectin business.industry cardiovascular disease (CVD) Paleontology medicine.disease lipid profile 030104 developmental biology Space and Planetary Science Rheumatoid arthritis Resistin lipids (amino acids peptides and proteins) lcsh:Q Lipid profile business |
| Zdroj: | Life, Vol 10, Iss 330, p 330 (2020) Life Volume 10 Issue 12 |
| ISSN: | 2075-1729 |
| Popis: | Apolipoprotein E (ApoE) polymorphism and adipokines are linked to atherosclerosis. We aimed to investigate the associations of apoE genotypes with adipokines, inflammatory parameters, and cardiovascular disease (CVD) risks in rheumatoid arthritis (RA) patients. We enrolled 152 RA patients and 49 healthy control (HC) subjects. The apoE genotyping was determined by a polymerase chain reaction, while plasma levels of adipokines and inflammatory cytokines were measured with ELISA. Although apoE genotypes distributions were indistinguishable between RA patients and HC, we found significantly higher levels of apoE and adipokines in RA patients compared with HC. RA patients with &epsilon 2&epsilon 3 genotype had lower levels of TNF-&alpha IL-6, resistin, and visfatin, but higher leptin levels compared with &epsilon 3&epsilon 3 genotype patients. Patients with &epsilon 4 genotype had significantly higher low-density lipoprotein-cholesterol (LDL-C) levels and atherogenic index scores compared with &epsilon 3 genotype carriers. Moreover, patients with &epsilon 3 genotype had significantly lower 10-year CVD risk than &epsilon 3 or &epsilon 4 genotype patients. &epsilon 4 genotype and adiponectin levels were independent predictors of a high 10-year CVD risk. RA patients with &epsilon 3 genotype are associated with lower levels of TNF-&alpha IL-6, resistin, visfatin, and CVD risk, while RA patients with &epsilon 4 genotype exhibited higher levels of LDL-C, insulin resistance, and higher CVD risks. |
| Databáze: | OpenAIRE |
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