Coexistence of delta sleep-inducing peptide and serotonin in midgut carcinoid tumour cells in vivo and in vitro
| Autor: | Ola Nilsson, Anders Bjartell, Rolf Ekman, Håkan Ahlman, Annica Dahlström, L. Ahlund |
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| Rok vydání: | 1989 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology Serotonin Biopsy Cell Immunocytochemistry Carcinoid Tumor Biology In Vitro Techniques Delta Sleep-Inducing Peptide In vivo Internal medicine Intestinal Neoplasms medicine Tumor Cells Cultured Humans Immunohistochemistry In vitro Pentagastrin Endocrinology medicine.anatomical_structure Oncology Cell culture Lymphatic Metastasis Delta sleep-inducing peptide Lymph Nodes medicine.drug |
| Zdroj: | International journal of cancer. 44(4) |
| ISSN: | 0020-7136 |
| Popis: | By immunocytochemistry, delta sleep-inducing peptide (DSIP) was demonstrated to coexist with serotonin (5-HT) in a majority of midgut carcinoid tumour cells studied in biopsies and long-term cell cultures. Tumour cell colonies were characterized ultrastructurally and by confocal laser microscopy. The cultures produced several DSIP-like peptides chromato-graphically separated from culture media. DSIP has not yet proved to be a useful tumour marker clinically. Provocation with pentagastrin in patients with midgut carcinoid syndrome resulted in increased peripheral levels of 5HT, but not of DSIP. |
| Databáze: | OpenAIRE |
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