Prospective Study on Body Composition, Energy Balance and Biological Factors Changes in Post-menopausal Women with Breast Cancer Receiving Adjuvant Chemotherapy Including Taxanes

Autor: Isabelle Van-Praagh, Marie-Ange Mouret-Reynier, Xavier Durando, Emilie Thivat, Emilie Gadéa, Pauline Herviou, Pascale Dubray-Longeras, Martine Duclos, Angeline Ginzac, Béatrice Morio, Joyce Dohou, Marie Arbre
Přispěvatelé: Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Imagerie Moléculaire et Stratégies Théranostiques - Clermont Auvergne (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre Jean Perrin, CRLCC Jean Perrin, Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Cancer Research
Adjuvant chemotherapy
medicine.medical_treatment
Medicine (miscellaneous)
Physiology
Breast Neoplasms
Hyperlipidemias
[SDV.CAN]Life Sciences [q-bio]/Cancer
Post menopausal
Anxiety
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Breast cancer
Antineoplastic Combined Chemotherapy Protocols
[SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Medicine
Glucose homeostasis
Humans
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Exercise
Aged
Chemotherapy
Lost Weight
Nutrition and Dietetics
business.industry
Age Factors
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
Middle Aged
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
medicine.disease
3. Good health
Postmenopause
Oncology
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Body Composition
Female
Taxoids
medicine.symptom
business
Energy Metabolism
Weight gain
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: Nutrition and Cancer
Nutrition and Cancer, 2018, 70 (7), pp.1-10. ⟨10.1080/01635581.2018.1502330⟩
Nutrition and Cancer, Taylor & Francis (Routledge), 2018, 70 (7), pp.997-1006. ⟨10.1080/01635581.2018.1502330⟩
Nutrition and Cancer, Taylor & Francis (Routledge), 2018, 70 (7), pp.1-10. ⟨10.1080/01635581.2018.1502330⟩
Nutrition and Cancer, Taylor & Francis (Routledge), 2018, pp.1-10. ⟨10.1080/01635581.2018.1502330⟩
ISSN: 0163-5581
1532-7914
DOI: 10.1080/01635581.2018.1502330⟩
Popis: International audience; In breast cancer patients, weight and fat mass changes observed after chemotherapy have been related to poor prognosis but some recent works using modern chemotherapy failed to find this correlation with weight gain. In this study, the extent of changes in weight and body composition (DEXA, impedance) was characterized until six months after current chemotherapy, in 50 post-menopausal women with breast cancer. The evolution of factors contributing to the energy balance and some biological factors were also described. During chemotherapy, 20% of women lost weight due to both fat (-13.1% ± 10.3) and lean soft tissue mass loss (-3.6% ± 4.6). Twenty percent of women gained weight. No significant fat mass gain was observed in these women but significant water gain was highlighted. Six months later, women who gained weight presented a gain in fat mass (15.4% ± 19.0), especially in the abdominal region. Age and initial BMI were negatively correlated with fat mass in multivariate analyzes (r = 0.486, P = 0.0030). No significant variation of the glucose homeostasis, triglycerides, and HDL-Cholesterol was found six months after chemotherapy. These results do not suggest major adverse metabolic disturbances six months after modern chemotherapy and only a mild fat mass gain was observed in women who gained weight.
Databáze: OpenAIRE
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