A constitutive model for developing blood clots with various compositions and their nonlinear viscoelastic behavior
| Autor: | Ths Thomas van Kempen, Frans N. van de Vosse, Gwm Gerrit Peters, WP Wouter Donders |
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| Přispěvatelé: | RS: MHeNs - R3 - Neuroscience, Promovendi MHN, Biomedische Technologie, RS: CARIM School for Cardiovascular Diseases, RS: CARIM - R2.09 - Cardiovascular system dynamics, Cardiovascular Biomechanics, Processing and Performance |
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Sus scrofa Physics::Medical Physics 0206 medical engineering Constitutive equation Large amplitude oscillatory shear (LAOS) 02 engineering and technology 030204 cardiovascular system & hematology Models Biological Viscoelasticity Quantitative Biology::Cell Behavior 03 medical and health sciences Oscillatory shear 0302 clinical medicine Rheology Modelling and Simulation Animals Whole blood Original Paper Blood clotting Viscosity Generalized Maxwell model Mechanical Engineering Thrombosis Mechanics Mechanical modeling 020601 biomedical engineering Elasticity Biomechanical Phenomena Nonlinear system Nonlinear Dynamics Modeling and Simulation Stress Mechanical Sensitivity analysis Biotechnology Biomedical engineering |
| Zdroj: | Biomechanics and Modeling in Mechanobiology Biomechanics and modeling in mechanobiology, 15(2), 279-291. Springer Biomechanics and Modeling in Mechanobiology, 15(2), 279-291. Springer |
| ISSN: | 1617-7940 1617-7959 |
| DOI: | 10.1007/s10237-015-0686-9 |
| Popis: | The mechanical properties determine to a large extent the functioning of a blood clot. These properties depend on the composition of the clot and have been related to many diseases. However, the various involved components and their complex interactions make it difficult at this stage to fully understand and predict properties as a function of the components. Therefore, in this study, a constitutive model is developed that describes the viscoelastic behavior of blood clots with various compositions. Hereto, clots are formed from whole blood, platelet-rich plasma and platelet-poor plasma to study the influence of red blood cells, platelets and fibrin, respectively. Rheological experiments are performed to probe the mechanical behavior of the clots during their formation. The nonlinear viscoelastic behavior of the mature clots is characterized using a large amplitude oscillatory shear deformation. The model is based on a generalized Maxwell model that accurately describes the results for the different rheological experiments by making the moduli and viscosities a function of time and the past and current deformation. Using the same model with different parameter values enables a description of clots with different compositions. A sensitivity analysis is applied to study the influence of parameter variations on the model output. The relative simplicity and flexibility make the model suitable for numerical simulations of blood clots and other materials showing similar behavior. Electronic supplementary material The online version of this article (doi:10.1007/s10237-015-0686-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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