Anti–HIV indeterminate Western blot in dialysis patients: A long-term follow-up
| Autor: | N. Vardinon, David Modai, Adrian Iaina, Israel Yust, Michael Burke, Osnat Katz, Ze'ev Katzir |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Blotting Western Blood Donors HIV Infections HIV Antibodies Gastroenterology Immunoenzyme Techniques Renal Dialysis Internal medicine ABO blood group system Immunopathology Humans Medicine False Positive Reactions biology business.industry Autoantibody medicine.disease biology.organism_classification Nephrology Immunology Lentivirus Blood Group Antigens biology.protein Kidney Failure Chronic Hemodialysis Viral disease Antibody business Follow-Up Studies Kidney disease |
| Zdroj: | American Journal of Kidney Diseases. 34:146-149 |
| ISSN: | 0272-6386 |
| DOI: | 10.1016/s0272-6386(99)70121-6 |
| Popis: | In a group of 520 patients undergoing chronic hemodialysis, 23 (4.4%) were enzyme immunoassay (EIA) positive for human immunodeficiency virus (HIV) and indeterminate by Western blot (IWB) analysis. The antibodies were mostly directed against p24 and p55 antigens. A comparison between hemodialysis patients with and without IWB showed significant differences between the two groups with respect to number of units of blood transfused, history of renal transplant rejection, and Rh status. No significant differences were observed with respect to ethnic group, nature of renal disease, duration of hemodialysis, associated diseases, and ABO blood group. The HIV IWB phenomenon may represent abnormal immune reactivity as a result of transplantation antigens and/or autoantibody formation. Five-year follow-up of the HIV EIA-positive IWB patients showed that none had seroconverted to HIV-positive status. |
| Databáze: | OpenAIRE |
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