Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open-Angle Glaucoma
| Autor: | Mehdi Yasseri, Sasan Moghimi, Parisa Abdi, Katayoon B. Ebrahimi, Marjan Afzali, Masoud Aghsaei Fard |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Retinal Ganglion Cells medicine.medical_specialty Visual acuity genetic structures Open angle glaucoma Nerve fiber layer Visual Acuity Glaucoma Severity of Illness Index Optic neuropathy 03 medical and health sciences 0302 clinical medicine Nerve Fibers Macula Lutea Ophthalmology medicine Humans Optic Neuropathy Ischemic Intraocular Pressure Retrospective Studies business.industry Ischemic optic neuropathy Middle Aged medicine.disease eye diseases medicine.anatomical_structure Cross-Sectional Studies Chronic Disease 030221 ophthalmology & optometry Anterior ischemic optic neuropathy Female sense organs medicine.symptom Visual Fields business 030217 neurology & neurosurgery Glaucoma Open-Angle Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Investigative ophthalmologyvisual science. 57(3) |
| ISSN: | 1552-5783 |
| Popis: | PURPOSE To compare the pattern of macular ganglion cell plus inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thickness changes in moderate to severe primary open-angle glaucoma (POAG) with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography (OCT) auto-segmentation. METHODS A total of 138 eyes (42 eyes with chronic unilateral NAION and their 42 unaffected fellow eyes, 32 eyes of 32 moderate to severe glaucoma patients, and 22 eyes of 22 healthy normal subjects) underwent neuro-ophthalmologic examinations and spectral-domain OCT in a cross-sectional study at a single academic institution. GCIPL and total retinal thicknesses were obtained from 20° by 20° cube scans of the macula centered around the fovea. The scanned region was divided into two concentric regions (inner and outer, with diameters of 3 and 6 mm, respectively) and eight sectors (four sectors in each of the inner and outer regions). Peripapillary RNFL thickness was also measured. RESULTS Peripapillary RNFL, total macula, and GCIPL were significantly thinner in NAION and POAG eyes compared to unaffected fellow eyes of NAION and to age-matched healthy control eyes in all eight sectors (P < 0.001). There was no significant difference in peripapillary RNFL, total macula, and outer region GCIPL thicknesses between the affected eyes of the patients with NAION and glaucoma patients. However, the inner region GCIPL was significantly thinner in NAION eyes compared to POAG eyes after adjusting for age, sex, and mean deviation of the visual field (P = 0.001). Also, the GCIPL sector thicknesses were more strongly correlated with visual acuity than were the macular sectors in all patients (most sectors P ≤ 0.001). CONCLUSIONS Patients with NAION show differences in the tissue damage with greater loss of parafoveal GCIPL tissue thickness compared to patients with POAG. |
| Databáze: | OpenAIRE |
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