Expression of vimentin (VIM) and metastasis-associated 1 (MTA1) protein in laryngeal squamous cell carcinoma are associated with prognostic outcome of patients
| Autor: | Efthimios Kyrodimos, Ioannis Giotakis, Agapi Kataki, Andreas M. Lazaris, Fani Karagianni, Evangelos Giotakis, Sotirios Karamagkiolas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Gene Expression Vimentin Metastasis 03 medical and health sciences Tumor Biomarkers 0302 clinical medicine Internal medicine Biomarkers Tumor Medicine Humans Receptor Notch1 030223 otorhinolaryngology Laryngeal Neoplasms Survival analysis Aged High rate Aged 80 and over biology business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Middle Aged Laryngeal squamous cell carcinoma medicine.disease Prognosis Immunohistochemistry Repressor Proteins Survival Rate Otorhinolaryngology 030220 oncology & carcinogenesis biology.protein Trans-Activators Female business |
| Zdroj: | American journal of otolaryngology. 40(4) |
| ISSN: | 1532-818X |
| Popis: | Purpose Laryngeal squamous cell carcinoma (LSCC), a common type of head and neck cancer, is associated with high rates of metastasis and recurrence. In this study, we investigated the potential combinatorial prognostic value of NOTCH1, Vimentin (VIM), and Metastasis-associated 1 (MTA1) protein in LSCC, using immunohistochemistry. Materials and methods Tissue specimens from 69 patients with LSCC were immunohistochemically evaluated for the protein expression of NOTCH1, VIM, and MTA1. Then, biostatistical analysis was performed, in order to assess the prognostic value of the expression of each one of these proteins. Results NOTCH1 expression status was not a significant prognosticator in LSCC, as shown in Kaplan-Meier survival analysis. On the contrary, both VIM and MTA1 seem to have an important prognostic potential, independently of TNM staging and histological grade of the tumor. In fact, positive VIM expression was shown to predict patients' relapse and poor outcome regarding patients' overall survival, in contrast with MTA1, the positive expression of which predicts higher disease-free survival (DFS) and overall survival (OS) rates in LSCC. Conclusions VIM and MTA1 constitute potential tumor biomarkers in LSCC and could be integrated into a multiparametric prognostic model. Undoubtedly, their prognostic value needs further validation in larger cohorts of LSCC patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect