Understanding and Interrupting the Fischer Azaindolization Reaction
| Autor: | Neil K. Garg, Elias Picazo, Kendall N. Houk, Marie Hoffmann, Pier Alexandre Champagne, Lucas A. Morrill, Bryan J. Simmons, Katsuya Yamakawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Aza Compounds
Indoles 010405 organic chemistry Hydrazine Synthetic Substituent Chemistry Techniques General Chemistry Chemistry Techniques Synthetic 010402 general chemistry 01 natural sciences Biochemistry Catalysis Article 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Hydrazines chemistry Chemical Sciences Organic chemistry |
| Zdroj: | Journal of the American Chemical Society, vol 139, iss 42 |
| Popis: | Experimental and computational studies pertaining to the Fischer azaindolization reaction are reported. These studies explain why pyridylhydrazines are poorly reactive in Fischer indolization reactions, in addition to the origin of hydrazine substituent effects. Additionally, an interrupted variant of Fischer azaindolization methodology is disclosed, which provides a synthetic entryway into fused azaindoline scaffolds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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