Sumoylation and phosphorylation: hidden and overt links
| Autor: | Ella Nukarinen, Nikola Winter, Jorge Vicente, Andreas Bachmair, Konstantin Tomanov, Guillermina M. Mendiondo, Markus Teige, Lilian Nehlin, Michael J. Holdsworth, Wolfram Weckwerth |
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| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Plant growth Proteome Physiology SUMO protein Sumoylation Plant Science Biology Proteomics 01 natural sciences Cell biology 03 medical and health sciences Sumo conjugation 030104 developmental biology Small Ubiquitin-Related Modifier Proteins Phosphorylation Protein phosphorylation 010606 plant biology & botany Plant Proteins |
| Zdroj: | Journal of experimental botany. 69(19) |
| ISSN: | 1460-2431 |
| Popis: | Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act interdependently to modulate stress responses. In particular, many components of the SUMO conjugation system are phosphoproteins, and some regulators and enzymes of protein phosphorylation can be sumoylated. Equally important, however, a number of proteins can be subject to both modifications. These substrates also have the capacity to connect stimuli transmitted via sumoylation with those transmitted via phosphorylation. As a prime example, we review data suggesting that nitrate reductase is a hub that integrates cues from these two modifications. Powerful proteomics approaches allowed the identification of additional common substrates, paving the way for studies to understand, on a broader basis, the cross-talk of phosphorylation with sumoylation and how it contributes to plant growth. |
| Databáze: | OpenAIRE |
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