Expression of 'Connexin 43' in Colorectal Carcinomas: Histopathological and Immunohistochemical Study
| Autor: | Lubna O. Abdel-Salam, Ahmed N. Eesa, Rabab Radi, Essam Ayad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Colorectal cancer Gap junction lcsh:R H&E stain Cancer Connexin lcsh:Medicine 030209 endocrinology & metabolism General Medicine Colorectal adenoma medicine.disease Immunohistochemistry 03 medical and health sciences 0302 clinical medicine Cx 43 medicine Carcinoma 030212 general & internal medicine business |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences, Vol 8, Iss A (2020) Open Access Macedonian Journal of Medical Sciences; Vol. 8 No. A (2020): A-Basic Sciences; 354-359 |
| ISSN: | 1857-9655 |
| Popis: | BACKGROUND: Colorectal cancer is one of the most common cancers worldwide and leading cause of cancer related deaths. Connexins are integral membrane proteins that form channels between adjacent cells. Gap junction intercellular communication plays essential roles in tissue homoeostasis and regulation of cell growth and differentiation. Connexins can act as either tumor suppressors or tumor promoters. The human connexin protein family contains 21 members, of which the most widely studied is connexin 43 (Cx 43). OBJECTIVES: Investigation of immunohistochemical expression of Cx 43 in cases of colorectal adenoma and carcinoma and correlation of this expression with the clinico-pathological aspects of the tumors. MATERIALS AND METHODS: Seventy formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients’ reports. The paraffin blocks were sectioned and stained with hematoxylin and eosin stains for histologic evaluation. Additional sections were immunostained with Cx 43. RESULTS: Cx 43 expression was negative in all studied cases. CONCLUSION: Cx 43 is a tumor suppressor that is lost early in colorectal carcinogenesis and can be considered as potential target for cancer chemoprevention and chemotherapy aiming at restoration of normal connexin expression and functional gap junctions. |
| Databáze: | OpenAIRE |
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