Chronotoxicity as Related to Chronobiology
| Autor: | M. Menon, M. Afzal, D. V. Parke, M.S.I. Dhami, M. Faisal Dhami |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Chronobiology Phenomena
Chronobiology business.industry Threshold limit value Risk Assessment Xenobiotics chemistry.chemical_compound Work shift chemistry Adverse health effect Occupational Exposure Work Schedule Tolerance Environmental health Humans Medicine Pharmacology (medical) Threshold Limit Values business Xenobiotic Occupational Health Melatonin |
| Zdroj: | Drug Metabolism and Drug Interactions. 13 |
| ISSN: | 2191-0162 0792-5077 |
| DOI: | 10.1515/dmdi.1997.13.4.231 |
| Popis: | This review focuses primarily on the complexities of chronotoxicity and chronopharmacology (time-of-day effects on the metabolism of environmental chemicals and therapeutic agents as related to chronobiology). The nature of the melatonin signal may modify the function of the hepatic endoplasmic reticulum resulting in variations in the metabolism of xenobiotic chemicals. Concepts are explored for modification of exposure limits and/or Threshold Limit Values (TLVs) of industrial chemicals in risk assessment and health effects of workers on rotating shifts. The TLVs of chemicals may be changed during work shift schedules to minimize adverse health effects among workers. |
| Databáze: | OpenAIRE |
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