Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study
| Autor: | Rachel S. Newby, Rami J. Salib, Raymond N. Allan, Matthew Dryden |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.drug_class 030106 microbiology Antibiotics medicine.disease_cause Cystic fibrosis Pathology and Forensic Medicine Microbiology Haemophilus influenzae 03 medical and health sciences Antibiotic resistance Bacteriology otorhinolaryngologic diseases Medicine Reactive Oxygen business.industry Biofilm General Medicine Antimicrobial medicine.disease 030104 developmental biology Otitis medicine.symptom business |
| Popis: | The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis and chronic obstructive pulmonary disease. Biofilm formation has been implicated in NTHi colonisation, persistence of infection and recalcitrance towards antimicrobials. There is therefore a pressing need for the development of novel treatment strategies that are effective against NTHi biofilm-associated diseases. SurgihoneyRO is a honey-based product that has been bioengineered to enable the slow release of H2O2, a reactive oxygen species to which H. influenzae is susceptible. Treatment of established NTHi biofilms with SurgihoneyRO significantly reduced biofilm viability through enhanced H2O2 production and was shown to be more effective than the conventional antibiotic co-amoxiclav. |
| Databáze: | OpenAIRE |
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