Discriminative Dissolution Method for Benzoyl Metronidazole Oral Suspension
| Autor: | Fabiana Ernestina Barcellos Da Silva, Aline Santos da Silva, Carlos Eduardo Da Rosa Silva, Fávero Reisdorfer Paula |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Chemistry Pharmaceutical Kinetics Pharmaceutical Science Administration Oral 02 engineering and technology Aquatic Science Pharmaceutical formulation 030226 pharmacology & pharmacy High-performance liquid chromatography Discriminatory power 03 medical and health sciences 0302 clinical medicine Metronidazole Drug Discovery Dissolution testing Particle Size Dissolution Ecology Evolution Behavior and Systematics Chromatography Ecology Gastric fluid Metronidazole Oral Suspension General Medicine 021001 nanoscience & nanotechnology Solubility 0210 nano-technology Agronomy and Crop Science |
| Zdroj: | AAPS PharmSciTech. 17(3) |
| ISSN: | 1530-9932 |
| Popis: | A dissolution method for benzoyl metronidazole (BMZ) oral suspensions was developed and validated using a high-performance liquid chromatography (HPLC) method. After determination of sink conditions, dissolution profiles were evaluated using different dissolution media and agitation speeds. The sample insertion mode in dissolution media was also evaluated. The best conditions were obtained using a paddle, 50 rpm stirring speed, simulated gastric fluid (without pepsin) as the dissolution medium, and sample insertion by a syringe. These conditions were suitable for providing sink conditions and discriminatory power between different formulations. Through the tested conditions, the results can be considered specific, linear, precise, accurate, and robust. The dissolution profiles of five samples were compared using the similarity factor (f 2) and dissolution efficiency. The dissolution kinetics were evaluated and described by the Weibull model. Whereas there is no monograph for this pharmaceutical formulation, the dissolution method proposed can be considered suitable for quality control and dissolution profile comparison of different commercial formulations. |
| Databáze: | OpenAIRE |
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