Preparedness and activities of the anti-SARS-CoV-2 convalescent plasma bank in the Veneto region (Italy): An organizational model for future emergencies
| Autor: | Monica Castelli, Marianna Rinaldi, Francesca Stefani, Gianluca Gessoni, Giorgio Gandini, Francesco Fiorin, Giustina De Silvestro, Ersilia Barbone, Arianna Veronesi, Monia Pacenti, Giovanni Roveroni, Piero Marson, Andrea Frigato, Monica Rizzi |
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| Rok vydání: | 2021 |
| Předmět: |
Blood transfusion
Convalescent plasma medicine.medical_treatment Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Blood Safety Organizational model Blood Donors 030204 cardiovascular system & hematology Antibodies Viral Article Donor Selection 03 medical and health sciences Plasma 0302 clinical medicine Pandemic Cost analysis Medicine Humans Pandemics COVID-19 Serotherapy Blood-Borne Infections business.industry SARS-CoV-2 Immunization Passive Outbreak COVID-19 Civil Defense Hematology medicine.disease Antibodies Neutralizing Italy Blood banking Preparedness Models Organizational Costs and Cost Analysis Blood Banks Virus Inactivation Medical emergency business 030215 immunology |
| Zdroj: | Transfusion and Apheresis Science |
| ISSN: | 1473-0502 |
| Popis: | Background Convalescent plasma (CP) has been used in the past in various pandemics, in particular in H1N1, SARS and MERS infections. In Spring 2020, when ongoing the SARS-CoV-2 pandemics, the Veneto Region (V-R) has proposed setting-up an anti-SARS-CoV-2 CP (CCP) Bank, with the aim of preparing a supply of CCP immediately available in case of subsequest epidemic waves. Materials and Methods Key-points to be developed for a quick set-up of the V-R CCP Bank have been recruitment of donors recovered from COVID-19 infection, laboratory analysis for the biological qualification of the CCP units, including titre of neutralizing antibodies and reduction of pathogens, according to National Blood Centre (CNS) Directives, adaptation of the V-R Information Technology systems and cost analysis. Some activities, including diagnostic and viral inactivation processes, have been centralized in 2 or 3 sites. Laboratory analysis upon preliminary admission of the donor included all tests required by the Italian laws and the CNS directives. Results From April to August 2020, 3,298 people have contacted the V-R Blood Transfusion Services: of these, 1,632 have been evaluated and examined as first time donors and those found to be suitable have carried out 955 donations, from which 2,626 therapeutic fractions have been obtained, at a cost around 215,00 Euro. Since October 2020, the number of COVID-19 inpatients has had a surge with a heavy hospital overload. Moreover, the high request of CCP therapy by clinicians has been just as unexpected, showing a wide therapeutic use. Conclusions The organizational model here presented, which has allowed the rapid collection of a large amount of CCP, could be useful when facing new pandemic outbreaks, especially in low and middle income countries, with generally acceptable costs. |
| Databáze: | OpenAIRE |
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